| Japanese |
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| Title | 人工心肺中の脳血流速度とサイアミラール投与による影響について |
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| Subtitle | 原著 |
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| Authors | 松本晶平, 小沢拓郎, 神里潔, 西山隆久, 渡辺省五, 畑山聖, 木下幸大, 石井脩夫 |
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| Authors(kana) | |
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| Organization | 東京医科大学麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 14 |
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| Number | 2 |
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| Page | 187-191 |
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| Year/Month | 1993/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」心疾患のため体外循環を用いて手術を行う症例において, 中大脳動脈の血流速度をTranscranial Doppler(TCD)を用いて検討した. サイアミラール使用群4例, および非使用群4例の2群に分類した. 全例大量フェンタニール麻酔で導入後, 右または左側頭部にTCDプローベを固定し, 持続的に中大脳動脈血流速度をモニターした. 人工心肺によるtotal perfusion開始後, サイアミラール4mg・kg-1を投与した. 全身血圧(潅流圧)は非投与群はほとんど変化しなかったが, 投与群では, 投与後有意に低下したが, 10分で回復した. 脳血流速度は投与群が非投与群に対し, 20分間にわたり有意な低値を示した. 脳血流速度の低下は脳血管抵抗の上昇を示唆するもので, このことから, サイアミラールの脳血管収縮薬としての作用が確認された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Cerebral blood flow velocity, Thiamylal, Cardiopulmonary bypass, Transcranial Doppler |
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| English |
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| Title | Changes of cerebral blood flow velocity affected by thiamylal administered during cardiopulmonary bypass |
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| Subtitle | |
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| Authors | Shohei Matsumoto, Takuro Ozawa, Kiyoshi Kamisato, Takahisa Nishiyama, Seigo Watanabe, Kiyoshi Hatakeyama, Kohdai Kinoshita, Nagao Ishii |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology,Tokyo Medical College |
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| Journal | Circulation Control |
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| Volume | 14 |
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| Number | 2 |
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| Page | 187-191 |
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| Year/Month | 1993/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The authors measured the cerebral blood flow velocity in the middle cerebral artery in cases of cardiac anesthesia at our hospital using a transcranial Doppler technique (TCD), and studied the effects of changes in the cerebral blood flow velocity and in the administration of barbiturate during cardiopulmonary bypass. The patients were divided into two groups: the thiamylal administration group and the group without thiamylal. After induction of anesthesia with a high dose of fentanyl in each patient, TCD probes were attached to either the left or right sides of the head, and the blood flow velocity in the middle cerebral artery was monitored continuously. After the start of total perfusion with the cardiopulmonary bypass, 4 mg・kg-1 of thiamylal was administered. The mean blood pressure (perfusion pressure) remained the baseline level in the group without thiamylal, but in the thiamylal group, it dropped significantly after administration and then recovered within 10 minutes. In the thiamylal group, the velocity dropped immediately after administration, and the value was significantly lower than that in the untreated group for 20 minutes. Decease of cerebral blood flow velocity in these cases, suggested an increase of cerebral vascular resistance. This result indicate that thiamylal is effective as a cerebral vasoconstrictor. |
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| Practice | Basic medicine |
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| Keywords | Cerebral blood flow velocity, Thiamylal, Cardiopulmonary bypass, Transcranial Doppler |
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