| Japanese |
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| Title | 低血圧時の神経性循環制御における迷走神経の役割 |
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| Subtitle | 特集 誌上シンポジウム ＝循環制御機構における神経・体液性因子の相互作用＝ |
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| Authors | 芝本利重, 小山省三 |
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| Organization | 信州大学医学部第2生理学教室 |
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| Journal | 循環制御 |
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| Volume | 14 |
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| Number | 3 |
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| Page | 243-249 |
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| Year/Month | 1993/ |
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| Article | 報告 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」低血圧(50mmHg, 10分間)時の神経性循環制御における求心性迷走神経の役割を検討する目的で麻酔下雑種成犬の腎臓, 心臓, 肝臓, 副腎, および脾臓の遠心性交感神経活動を同時測定した. 低血圧は出血および心タンポナーデさらに下大静脈閉塞によって誘発した. その結果, すべての交感神経活動はいずれの低血圧状態でも直ちに増加し, 動脈系圧受容器と低圧系圧受容器からの加算的賦活効果が認められた. しかし, その後低血圧の持続にともなって低血圧前値に向かって抑制を認めた. 特に腎交感神経では求心性迷走神経の関与によって低血圧発生前値以下に抑制された. また10分間の下大静脈閉塞によって誘発した低血圧状態を解除したのちの圧受容器の反射性応答の感度は一過性に低下しており, この抑制反応には求心性迷走神経が関与していた. さらに低血圧状態の解除後に出現する反射性感度の低下は神経性に誘発されたバゾプレッシンなどの体液性因子が関与している可能性があることが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | vagal afferents, sympathetic activity, systemic hypotension, bororeflex, vasopressin |
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| English |
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| Title | Role of vagal afferents in the neural control of circulation during systemic hypotension. |
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| Subtitle | |
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| Authors | Toshishige Shibamoto, Shozo Koyama |
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| Organization | Department of Physiology,Division 2,Shinshu University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 14 |
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| Number | 3 |
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| Page | 243-249 |
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| Year/Month | 1993/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Sympathetic outflow to the kidney, heart, liver, adrenal gland and spleen was measured by a direct multifiber and simultaneous recording during systemic hypotension of 50 mmHg for 10 min. Sustained hypotension was induced by hemorrhage, occlusion of the vena cava inferior and cardiac tamponade in anesthetized dogs with and without vagotomy. At an initial stage of hypotension all measured nerve activities equivocally increased followed by sympathoinhibition. This sympathoinhibition was mediated by vagal afferents. Vagal afferents also participated summatively in the initial increases in sympathetic nerve activities, together with arterial baroreflex. In addition, we determined the effect of systemic hypotension of 50 mmHg on the reflex sympathetic responsiveness to changes in blood pressure. Baroreflex sensitivity was transiently suppressed within 15 min after releasing systemic hypotension of 50 mmHg for 10 min due to inferior vena cava occlusion. Vagotomy or pretreatment with vasopressin receptor (V1) antagonist abolished this reduction of baroreflex sensitivity. This finding indicates that hypotension causes suppression of baroreflex sensitivity, which may be mediated by neurogenically released vasopressin. Vagal afferents play an important role in the neural regulation of circulation, interacting with effects of humoral factors during systemic hypotension. |
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| Practice | Basic medicine |
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| Keywords | vagal afferents, sympathetic activity, systemic hypotension, bororeflex, vasopressin |
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