| Japanese |
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| Title | Adriamycin心筋症におけるβ受容体を介するnoradrenaline遊離反応 |
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| Subtitle | 原著 |
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| Authors | 宇野嘉弘, 湊口信也, 今井洋子, 越路正敏, 各務雅夫, 横山仁美, 伊藤裕康, 平川千里 |
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| Organization | 岐阜大学附属病院第2内科 |
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| Journal | 循環制御 |
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| Volume | 14 |
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| Number | 3 |
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| Page | 307-312 |
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| Year/Month | 1993/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」交感神経末端遊離促進性β受容体を介するnoradrenaline(NA)遊離反応が, Adriamycin心筋症心不全において, どのようになっているかを検討するため, Adriamycin心筋症rabbit[日本白色種の雄, 体重2.5±0.04㎏：投与量1mg/kg, 週2回×8週間静注]を用い, pentobarbital麻酔下(70mg/kg bolus i.v., 15mg/kg/hr持続注入), adrenaline(0.06μg/kg/min)持続静注時の血漿NA濃度を測定(HPLC＋THI法), 無処置群(Vehicle群)と比較した. その結果, (1)adrenalineによる血漿NA濃度の増加は, Vehicle群(n＝7)に比して, adriamycin処置群(n＝7)にて, 有意に小であった. (2)Vehicle群において, adrenalineによる血漿NA濃度の増加はpropranololによってほぼ完全に抑制された. Adriamycin心筋症心不全において, 遊離促進性β受容体を介するNA遊離反応は, 低下していることが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Presynaptic β-adrenoceptors, adriamycin-induced cardiomyopathy, adrenaline, noradrenaline, pithed rabbit |
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| English |
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| Title | Modulation of noradrenaline release via release echancing β-adrenoceptors in rabbits with adriamycin-induced cardiomyopathy |
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| Subtitle | |
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| Authors | Yoshihiro Uno, Shinya Minatoguchi, Yoko Imai, Masatoshi Koshiji, Masao Kakami, Hitomi Yokoyama, Hiroyasu Ito, Senri Hirakawa |
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| Authors(kana) | |
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| Organization | Second Department of Internal Medicine School of Medicine,Gifu University |
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| Journal | Circulation Control |
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| Volume | 14 |
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| Number | 3 |
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| Page | 307-312 |
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| Year/Month | 1993/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We investigated the role of release-enhancing β-adrenoceptors in noradrenaline release in rabbits with cardiomyopathy produced by adriamycin (1 mg/kg, i.v., twice a week for 8 weeks). Plasma noradrenaline levels were measured before, 30 min and 60 min after the start of continuous intravenous administration of adrenaline (0.06 ug/kg/min) in adriamycin-treated and vehicle treated rabbits in anesthetized subjects. In anesthetized condition, adrenaline increased plasma noradrenaline levels in vehicle-treated rabbits. However, in the adriamycin-treated rabbits, adrenaline had no effect on the plasma noradrenaline level. Pretreatment with propranolol (0.2 mg/kg,bolus i.v.+0.1 mg/kg/hr, continuous infusion) almost completely abolished the rise in plasma noradrenaline level associated with adrenaline infusion in vehicle-treated rabbits. These results suggest that in rabbits with adriamycin-induced cardiomyopathy, the noradrenaline release from the sympathetic nerve endings via the activation of release enhancing β-adrenoceptors is reduced. |
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| Practice | Basic medicine |
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| Keywords | Presynaptic β-adrenoceptors, adriamycin-induced cardiomyopathy, adrenaline, noradrenaline, pithed rabbit |
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