| English |
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| Title | Current Concepts of Nitrate Therapy |
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| Subtitle | Review |
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| Authors | J.O.Parker |
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| Organization | Kingston General Hospital, Kidd 3 Cardiovascular Laboratory |
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| Journal | Circulation Control |
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| Volume | 14 |
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| Number | 4 |
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| Page | 509-519 |
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| Year/Month | 1993/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The organic nitrates have been employed for more than a century in the management of patients with coronary artery disease and myocardial ischemia. Lauder Brunton' described the beneficial effects of amyl nitrite in patients with angina pectoris in 1867 and William Murrell2) documented the efficacy of nitroglycerin (GTN) in patients with angina pectoris in 1879. He reported that patients with angina pectoris improved when a 1% solution of GTN was administered prophylactically and that patients obtained relief when they took this medication during an episode of angina pectoris. This was the first report of the efficacy of GTN as an agent for angina prophylaxis and also as a therapeutic intervention to treat episodes of ischemia. 「Mechanism of Action of the Nitrates」The organic nitrates are prodrugs and require a metabolic change to induce their therapeutic effects. This biodegradation occurs in vascular smooth muscle cells where the organic nitrate, in association with reduced sulfhydryl groups are denitrated to produce nitric oxide (NO). |
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| Practice | Basic medicine |
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