| Japanese |
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| Title | 終末呼気陽圧(PEEP)人工呼吸の臓器血液量に及ぼす影響 |
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| Subtitle | 原著 |
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| Authors | 福井明, 高折益彦, 木村健一, 藤田喜久 |
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| Authors(kana) | |
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| Organization | 川崎医科大学麻酔科学教室 |
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| Journal | 循環制御 |
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| Volume | 14 |
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| Number | 4 |
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| Page | 537-543 |
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| Year/Month | 1993/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」調節呼吸されたイヌにPEEPを負荷し, これによる循環血液量, 頭部, 胸部, 肝部, 脾部, 下腹部, 右大腿部の血液量の変化を経時的に測定した. この結果, PEEPを5, 10, 15, 20cmH2Oと上昇させるにしたがって, 循環血液量と胸部の血液量は減少し, 反対に肝, 脾, 下腹, 右大腿各部の血液量は増加した. とくに肝部における増加率が最大であった. またPEEP負荷は, 門脈, 大腿静脈の圧を上昇させ, 心拍出量を減少させた. したがってPEEPは各臓器への血流増加ではなく, 静脈側の血液貯留を発生させることを認めた. ただ, 頭部(特に脳)の血液量はPEEP 5cmH2Oで最大値を示し, 以後その増加は減少した. これらの変化はPEEP解除後少なくとも30分間は持続した. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | organ blood volume, PEEP |
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| English |
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| Title | The effect of positive end-expiratory pressure (PEEP) on the organ blood volume |
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| Subtitle | |
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| Authors | Akira Fukui, Masuhiko Takaori, Ken-ichi Kimura, Yoshihisa Fujita |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology,Kawasaki Medical School |
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| Journal | Circulation Control |
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| Volume | 14 |
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| Number | 4 |
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| Page | 537-543 |
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| Year/Month | 1993/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We observed changes in the circulating blood volume as well as regional blood volume, such as the brain, thoracic cavity, liver, spleen, lower abdomen, and right femoral skeletal muscles by loading PEEP on dogs under controlled ventilation. In the result, the circulating blood volume and the blood volume in the thoracic cavity decreased linearly in response to the increase in PEEP from 5 to 10, 15 and 20cmH2O, whereas blood volumes in the liver, spleen, lower abdomen and the right femoral skeletal muscles increased. At the same time, PEEP loading raised the portal and femoral venous pressures and decreased cardiac output. Hence, it was demonstrated that PEEP would cause accumulation of venous blood instead of increasing blood flow to various organs. However, the blood volume in the head(especially in the brain) reached the maximum (109±11%) at 5cmH2O PEEP. It started to decrease thereafter, but remained in 106±6% at 20cmH2O PEEP. The degree of increase in blood volume was the greatest (133±9%) in the liver. These chqnges tended to return toward the initial after PEEP had been relieved, but did not recover at all within at least 30 minutes. |
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| Practice | Basic medicine |
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| Keywords | organ blood volume, PEEP |
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