| Japanese |
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| Title | 肝循環調節機構に及ぼす動脈血, 門脈血の酸素分圧とpHの影響 |
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| Subtitle | 原著 |
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| Authors | 松本延幸, 黒木恭子, 菅井実, 林和人, 大原一成, 中村信一, 長坂浩, 堀孝郎 |
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| Organization | 埼玉医科大学麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 15 |
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| Number | 1 |
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| Page | 100-104 |
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| Year/Month | 1994/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」雑種イヌ14頭を使用し, 調節呼吸下に低濃度ハロタン麻酔(0.5−0.9MAC)を施行しながらFIO2を0.10に低下させた. この間に電磁流量計で肝動脈と門脈の血流量を測定して, 動脈血, 門脈血中の酸素分圧, pHの変化との関係を検討した. この結果, ハロタン麻酔では低濃度でも門脈血流量が減少した際に, 肝動脈緩衝反応(HABR)が抑制され肝動脈血流量の増加が認められなかったが, 低酸素刺激を加えると門脈血流量の変化は少なかったにもかかわらず, 肝動脈血流量は急激に増加した. この増加は動脈血, 門脈血中の酸素分圧, pHの変化と有意の負の相関関係が認められたところから, 血中の酸素分圧やpHの低下は, ハロセンによって抑制されていたHABRを回復させるか, または独自の調節機構によって肝動脈血流量を調節しているものと思われる. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | oxygen tension, pH, hepatic circulation, and hepatic arterial buffer response (HABR) |
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| English |
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| Title | Role of Blood O2 Tension and pH in Hepatic Circulatory Regulation. |
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| Subtitle | |
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| Authors | Nobuyuki Matsumoto, Kyoko Kuroki, Minoru Sugai, Kazuhito Hayashi, Kazushige Oohara, Shinichi Nakamura, Hiroshi Nagasaka, Takao Hori |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology,Saitama Medical School |
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| Journal | Circulation Control |
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| Volume | 15 |
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| Number | 1 |
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| Page | 100-104 |
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| Year/Month | 1994/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Hepatic arterial buffer response (HABR) could not always regulate hepatic arterial blood flow under general anesthesia. The present study was designed to determine whether some different factors from HABR would affect hepatic arterial blood flow during halothane anesthesia and hypoxia. Fourteen mongrel dogs were anesthetized by low concentration (0.5 - 0.9 MAC) of halothane while inhaling room air and hypoxic gas mixture (FiO2 0.10). Hepatic blood flow was measured using electromagnetic flowmetry. Correlations between a) arterial oxygen tension (PaO2) ; b) portal venous oxygen tension (PpvO2) ; c) arterial pH (pHa) ; d) portal venous pH (pHpv) and hepatic arterial blood flow were examined. Results were follows: 1) even subanesthetic concentration of halothane suppressed HABR, however, 2) once hypoxia was induced, hepatic arterial blood flow significantly increased without any relation to portal venous blood flow, and 3) the increase of hepatic arterial blood flow was significantly correlated with decreases of PaO2, PpvO2, pHa and pHpv. These results suggest that decreases of oxygen tension and pH in arterial and/or portal venous blood would exert an influence on hepatic blood flow by the recovery of HABR which had been depressed by halothane, or another mechanism except HABR. |
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| Practice | Basic medicine |
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| Keywords | oxygen tension, pH, hepatic circulation, and hepatic arterial buffer response (HABR) |
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