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| Title | Effects of Cardiac Sympathetic Nerve Stimulation on Coronary Artery and Myocardial Metabolism in the Dog with Coronary Stenosis |
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| Subtitle | |
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| Authors | Arifumi KOHYAMA, Shohzoh KAJI, Satoshi YASUMOTO, Hideyuki KIMURA, Hiroshi KITAHATA, Takao SAITOH |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology,Tokushima University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 15 |
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| Number | 1 |
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| Page | 105-111 |
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| Year/Month | 1994/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」The effects of cardiac sympathetic nerve stimulation on the myocardium and coronary artery in the heart with acutely produced coronary stenosis were studied and compared with normal heart (N=21). Intramyocardial pH in the inner layer of the myocardium distal to the stenosis was used to assess the myocardial ischemia. Coronary vascular resistance distal to the stenosis was calculated by coronary artery pressure distal to the stenosis and coronary blood flow through the stenosis. Electrical stimulation of cardiac sympathetic nerve did not change the heart rate, while mean aortic pressure increased by approximately 12 mmHg and maximal rate of rise of left ventricular pressure increased by about 700 mmHg・sec-1 in both groups. Although coronary blood flow increased in both groups significantly, coronary vascular resistance increased in the normal heart but failed to increase in the heart with stenosis. Intramyocardial pH did not change in the normal heart, but tended to fall from 7.12±0.10 to 7.10±0.11 in the heart with stenosis. These results suggested that in the heart with stenosis, cardiac sympathetic nerve stimulation increases coronary perfusion pressure and coronary blood flow through the stenosis, but the oxygen supply may have been insufficient for the myocardial oxygen demand in the inner layer distal to the stenosis, leading to worsening ischemia. |
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| Practice | Basic medicine |
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| Keywords | cardiac sympathetic nerve, coronary artery stenosis, myocardial metabolism |
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