| Japanese |
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| Title | Diadenosine tetraphosphate および Adenosine triphosphateによる低血圧麻酔時の体内血流分布への影響 |
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| Subtitle | 原著 |
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| Authors | 大岩悦郎 |
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| Authors(kana) | |
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| Organization | 帝京大学医学部麻酔科 |
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| Journal | 循環制御 |
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| Volume | 15 |
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| Number | 1 |
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| Page | 119-126 |
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| Year/Month | 1994/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」エンフルラン麻酔した14頭の雑種イヌを用いて, Diadenosine tetraphosphate(Ap4A)およびAdenosine triphosphate(ATP)により平均血圧をそれぞれ薬物投与前値より30.6±1.7及び30.8±0.9％低下させた時の体内血流分布の変化をMicrosphere法により検討した. Ap4AおよびATPはともに, 心, 副腎, 門脈系臓器の血流量を有意に増大させ, 脳血流量を維持し, 肝動脈, 骨格筋の血流量を有意に減少させた. 一方, Ap4Aが腎の血流量を有意に増大したのに対し, ATPは有意ではないが減少傾向を示し, 両薬物による体内血流分布には違いが生じた. また, 両者の違いは門脈系を司る各臓器の血流分布でも観察された. これらの結果によりAp4AおよびATPによる約30％の低血圧維持は虚血障害性の高い臓器の血流量を保持し, 骨格筋の血流量は減少しているが, 臓器保護を念頭においた体内血流分布の観点から優れた低血圧麻酔薬であることが示唆されたが, 腎血流量を減少させないAp4Aの方がATPより優れていた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | diadenosine tetraphosphate, adenosine triphosphate, fractional distribution of cardiac output, enflurane, induced hypatension |
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| English |
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| Title | Effects of diadenosine tetraphosphate or adenosine triphosphate on fractional distribution of cardiac output during enflurane anesthesia in dogs. |
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| Subtitle | |
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| Authors | Etsuro Ohiwa |
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| Authors(kana) | |
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| Organization | Department of anesthesiology,Teikyo University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 15 |
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| Number | 1 |
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| Page | 119-126 |
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| Year/Month | 1994/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「ABSTRACT」Using 14 mongrel dogs kept under enflurane anesthesia, mean arterial pressure was reduced by diadenosine tetraphosphate (Ap4A) and adenosine triphosphate (ATP) by 30.6±1.7% and 30.8±0.9% respectively from the pre-administration values, and changes of fractional distibution of cardiac output was evaluated by microsphere method. Both Ap4A and ATP significantly increased blood flow in heart, adrenal gland, and portal organ, maintained cerebral blood flow, and significantly decreased blood flow in hepatic artey and skeletal muscles. On the other hand, Ap4A significantly increased blood flow in kidney, while ATP tended to decrease it although not significantly, showing difference in fractional distribution of cardiac blood flow between the two drugs. The difference was also observed in blood flow distribution in the organs governing portal system. These results suggest that both Ap4A and ATP are excellent hypotensive anesthetic drugs from the viewpoint of fractional distribution of cardiac output with protection of organs in mind because each of the two drugs maintains hypotensive state by about 30%, holds blood flow in the organs with potential ischemic disorder and decreases blood flow in skeletal muscles. It seems that Ap4A has the better effect than ATP in that it does not decrease renal blood flow. |
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| Practice | Basic medicine |
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| Keywords | diadenosine tetraphosphate, adenosine triphosphate, fractional distribution of cardiac output, enflurane, induced hypatension |
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