| Japanese |
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| Title | 吸入麻酔薬の洞房結節に対する直接作用―選択的潅流における検討― |
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| Subtitle | 原著 |
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| Authors | 高地明*, 大和田哲郎**, 水口公信* |
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| Organization | *千葉大学医学部麻酔学教室, **成田赤十字病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 15 |
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| Number | 2 |
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| Page | 258-261 |
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| Year/Month | 1994/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」吸入麻酔薬の全身投与による影響を除外した選択的潅流法を用い, 吸入麻酔薬(ハロタン, エンフルラン, イソフルラン, セボフルラン；以下H, E, I, S)の洞房結節に対する直接作用をin situにおいて比較検討した. ペントバルビタール麻酔下のイヌを用い, 定常圧で洞房結節を, 0, 1, 2MACの吸入麻酔薬(H, E, I, S)で通気したKrebs-Ringer-bicarbonate溶液を用いて潅流を行った. 心拍数は, 1MACのEを投与しても大きな変化は認められなかったが, 2MACのE投与により有意に減少した. 1及び2MACのI投与により心拍数は有意に減少したが, 両者間の減少の程度に有意差はなかった. これに対し, 1, 2MACのH, Sを投与しても心拍数に大きな変化は認められなかった. 以上の結果から, 洞房結節に対し, a)E, Iは抑制的に作用し, b)H, Sは2MAC以下では抑制作用のないことが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | volatile anesthetics, sinoatrial node, direct perfusion technique |
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| English |
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| Title | Chronotropic Effects of Volatile Anesthetics on Sinoatrial Node in Situ -Use of Direct Perfusion Technique- |
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| Subtitle | |
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| Authors | A.Kouchi*, T.Ohwada**, T.Mizuguchi* |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology,Chiba University School of Medicine, **Department of Anesthesiology,Narita Red Cross Hospital |
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| Journal | Circulation Control |
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| Volume | 15 |
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| Number | 2 |
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| Page | 258-261 |
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| Year/Month | 1994/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We examied chronotropic effects of volatile anesthetics (halothane, enflurane, isoflurane, sevoflurane) on sinoatrial (SA) node in 12 mongrel dogs anesthetized with pentobarbital. The sinoatrial node area was selectively perfused using SP-35 catheter through the SA node artery with Krebs-Ringer-bicarbonate solution. One of the volatile anesthetics was dissolved in the solution at the concentrations of 1 and 2 MAC. We maintained the constant perfusion pressure of 150 mmHg , and the tempreture of the solution was kept at 37℃. The method allowed to restrict effects of the volatile anesthetics on the SA node. The changes in heart rate induced by volatile anesthetics were normalized by the control value, and the comparison was made among the control 1 and 2 MAC of each anesthetics. 1) Halthane and sevoflurane did not change the heart rate. 2) Enfurane and isoflurane significantly decreased heart rate dose-dependently compared with the control value. Our results indicate that halothane and sevoflurane have no influence on the SA node while enflurane and isoflurane have direct inhibitory action on the SA node. |
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| Practice | Basic medicine |
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| Keywords | volatile anesthetics, sinoatrial node, direct perfusion technique |
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