| Japanese |
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| Title | 冠動脈内エンドセリン投与時の冠血流量ならびに心筋代謝に及ぼす吸入麻酔薬の影響 |
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| Subtitle | 原著 |
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| Authors | 中山雅康, 藤田智 小林巌, 金谷憲明, 土田英昭, 並木昭義 |
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| Authors(kana) | |
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| Organization | 札幌医科大学医学部麻酔学講座 |
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| Journal | 循環制御 |
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| Volume | 15 |
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| Number | 2 |
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| Page | 262-267 |
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| Year/Month | 1994/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」機能的冠動脈狭窄による心筋虚血に対する吸入麻酔薬の保護作用を検討することを目的に, 冠動脈内にエンドセリンを直接注入して収縮を引き起こし, ハロタン(HAL)およびイソフルラン(ISO)が冠血流量ならびに心筋代謝に及ぼす影響を検討した. 雑種イヌを対象に3群に分類した. 対照群では, モルヒネ−ウレタン−α−クロラロースで, HAL群, ISO群ではそれぞれ0.5MACの吸入濃度で麻酔を維持した. 心筋虚血は, 左冠動脈前下行枝(LAD)内に15pmol/kgのエンドセリン-1(ET-1)を投下して作製した. ET-1投与後の冠血流量の低下は, HAL群28％, ISO群44％と対照群75％と低値を示し, 対照群とHAL群との間に有意差を認めた(p＜0.05). また, ET-1投与3分後のLAD領域の心筋代謝では, HAL群でエネルギーチャージポテンシャルの低下が, HAL群とISO群で乳酸の上昇が対照群より有意に抑制された(p＜0.05). 非虚血部の心筋代謝は, 各群間で有意差を認めなかった. 以上より, HALおよびISOはエンドセリンによる虚血の程度を軽減し, 保護的に作用することが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | halothane, isoflurane, endothelin, myocardial metabolism |
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| English |
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| Title | The Effects of Halothane and Isoflurane on Changes in the Ischemic Myocardial Metabolism Induced by Intracoronary Injection of Endothelin in Dogs |
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| Authors | Masayasu Nakayama, Satoshi Fujita, Iwao Kobayashi, Noriaki Kanaya, Hideaki Tuchida, Akiyoshi Namiki |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology,Sapporo Medical University,School of Medicine |
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| Journal | Circulation Control |
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| Volume | 15 |
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| Number | 2 |
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| Page | 262-267 |
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| Year/Month | 1994/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Endothelin (ET) is a vasoconstrictor and causes coronary artery constriction in humans. The purpose of this study was to determine if halothane (HAL) or isoflurane (ISO) attenuates the deterioration in the coronary artery blood flow (CBF) and the myocardial metabolism induceded by injection of ET into the left anterior descending coronary artery (LAD) in open chest mongrel dogs. Subjects were divided into three groups. In the control (C) group, anesthesia was maintained with morphine, urethane and α-chloralose. In the HAL or ISO group, 0.5 minimum alveolar concentration (MAC) of each anesthetic was inhalated during the study period. A 15-pmol/kg dose of ET-1 was injected retrogradely into the LAD of all subjects to produce myocardial ischemia. The reduction in CBF following the ET injection was smaller in the HAL (-28%) and ISO (-44%) groups than in the C group (-75%). Moreover, both HAL and ISO attenuated the decrease in the level of energy charge potential and the increase in lactate in the myocardium perfused by the LAD 3 min after the ET injection. These results suggested that both HAL and ISO show a protective effect on myocardial ischemia by ET and may be used safely in patients with unstable angina. |
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| Practice | Basic medicine |
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| Keywords | halothane, isoflurane, endothelin, myocardial metabolism |
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