| Japanese |
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| Title | プロタミン動脈内投与後の血圧低下に対するNOの関与 |
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| Subtitle | 原著 |
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| Authors | 小松博*, 円山敬司**, 戸部善継*, 鈴樹正大* |
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| Authors(kana) | |
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| Organization | *秋田大学医学部麻酔学教室, **秋田大学医学部附属病院救急部 |
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| Journal | 循環制御 |
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| Volume | 15 |
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| Number | 2 |
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| Page | 268-271 |
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| Year/Month | 1994/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」今回, プロタミンの動脈内投与後の血圧低下にNOが関与しているかどうかNOの競合的阻害剤であるNω-nitro-L-arginine-methyl ester(L-NNM)を用いて検討した. SD系雄性ラットをL-NNM前投与群と非投与群の2群に分け, プロタミン投与後の血圧の経時的変化について検討した. プロタミン投与後の血圧の最大低下率はL-NNM前投与群では26.7％, 非投与群では60.8％とL-NNM前投与群で有意に低値を示した. このことから, プロタミンによる血圧低下にはNOが関与していることが強く示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | nitric oxide, hypotension, protamine |
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| English |
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| Title | Role of Nitric Oxide on Systemic Hypotension Caused by Intra-arterial Injection of Protamine |
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| Subtitle | |
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| Authors | Hiroshi Komatsu*, Keiji Enzan**, Masahiro suzuki* |
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| Authors(kana) | |
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| Organization | *Department of Emergency Medicine,Akita University School of Medicine, **Department of anesthesiology,Akita University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 15 |
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| Number | 2 |
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| Page | 268-271 |
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| Year/Month | 1994/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We investigated whether nitric oxide (NO) plays an important role in systemic hypotension caused by protamine injection of 10 mg・kg-1. Rats were divided two groups. In L-NNM pretreatment group, L-NNM of 20 mg・kg-1 was given 5 min before protamine injection IA and in protamine group, protamine alone was given IA. In protamine group the maximal decrease in arterial pressure was 60.8 %, while in L-NNM group it was 26.7 %. These decreasses in arterial pressure were significant between two groups. When protamine was injected after heparin administration, the maximal decrease of arterial pressure was aproximately 5 %. Arterial pressure decresed dose-dependently after injection of either L-arginine or protamine. Decreases of arterial pressure after L-arginine administration in L-NNM pretretment rats were almost similar. We conclude that NO plays an important role in systemic hypotension caused by intra-arterial injection of protamine. |
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| Practice | Basic medicine |
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| Keywords | nitric oxide, hypotension, protamine |
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