| Japanese |
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| Title | 冠狭窄心における超短時間作用性β遮断薬ONO-1101の局所心筋酸素需給平衡に及ぼす影響 |
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| Subtitle | 原著 |
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| Authors | 阿部正, 木村英之, 北畑洋, 神山有史 |
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| Authors(kana) | |
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| Organization | 徳島大学医学部麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 15 |
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| Number | 2 |
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| Page | 277-282 |
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| Year/Month | 1994/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」超短時間作用性β遮断薬ONO-1101を冠動脈狭窄犬(n＝9)に対して投与し, その局所心筋酸素需給平衡に及ぼす影響を検討した. 冠動脈狭窄により29.0±10.7mmHgから20.2±9.9mmHgへと有意に低下した心筋内層酸素分圧値(PtiO2)はONO-1101の投与(2μg/kg/min)によって, 15分後27.6±13.2mmHg, 30分後30.0±15.4mmHgへと有意に上昇した. ONO-1101投与によるPtiO2の変化は心拍数の変化と有意な負の相関を, LV dp/dt maxの変化と有意な正の相関を示したが, 平均大動脈圧, 左室拡張終期圧, ratepressure product, pressure-rate quotientの変化との間には有意な相関をもたなかった. 心筋酸素需給平衡の改善は主として心拍数の減少と収縮力の低下にともなう心筋酸素消費量の減少によるものと考えられ, 急速なβ受容体遮断が望ましい周術期の心筋虚血患者に対してONO-1101の有用性が期待される. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | ultra short-acting β-blocker (ONO-1101), regional myocardial oxygen balance, myocardial ischemia |
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| English |
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| Title | Effects of ONO-1101, An Ultra Short-acting β-blocker, on Regional myocardial Oxygen Balance in the Canine Heart with Coronary Artery Stenosis |
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| Subtitle | |
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| Authors | Tadashi Abe, Hideyuki Kimura, Hiroshi Kitahata, Arifumi Kohyama |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology,University of Tokushima School of Medicine |
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| Journal | Circulation Control |
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| Volume | 15 |
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| Number | 2 |
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| Page | 277-282 |
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| Year/Month | 1994/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The effects of an ultra short-acting β-blocker ONO-1101 on regional myocardial oxygen balance were studied in 9 pentobarbital-anesthetized mongrel dogs with coronary artery stenosis. Regional myocardial oxygen balance was assessed by continuous recording of subendocardial oxygen tension. After the basal measurement, the left circumflex coronary artery blood flow was reduced by 20% with a screw flow regulator. The institution of stenosis caused a significant decline in subendocardial oxygen tension (from 29.0±10.7 mmHg to 20.2±9.9 mmHg). Otherwise, there were no significant differences between basal values and those after the stenosis. After 15 and 30 minutes of the initiation of ONO-1101 administration (2μg・kg-1・min-1) , subendocardial oxygen tension significantly increased to 27.6±13.2 mmHg and 30.4±15.4 mmHg respectively. The changes in subendocardial oxygen tension significantly correlated with those in heart rate and LV dp/dt max, but no significant correlation was found with those in aortic pressure, LVEDP, rate-pressure product, and pressure-rate quotient. It seems that regional myocardial oxygen balance was improved by reduction in myocardial oxygen consumption accompanied with decrease in heart rate and contractile force. The newly developed ultra short-acting β-blocker ONO-1101 could be used safely in patients suffered from perioperative myocardial ischemia and required rapid β-blockade. |
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| Practice | Basic medicine |
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| Keywords | ultra short-acting β-blocker (ONO-1101), regional myocardial oxygen balance, myocardial ischemia |
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