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| Title | Effects of Sympathetic Nerve Stimulation after Propranolol Administration on Coronary Artery and Myocardial Metabolism in the Dog with Coronary Stenosis |
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| Subtitle | Original article |
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| Authors | Arifumi Kohyama, Shozo Kaji, Satoshi Yasumoto, Hideyuki Kimura, Hiroshi Kitahara, Takao Saito |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Tokushima University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 15 |
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| Number | 3 |
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| Page | 415-420 |
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| Year/Month | 1994/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「ABSTRACT」The effects of cardiac sympathetic nerve stimulation after propranolol administration on coronary vascular resistance and myocardial metabolism were studied in 21 dogs with coronary artery stenosls. After administration of propranolol in the heart with stenosis, heart rate and maximal rate of rise of left ventricular pressure significantly decreased, whereas systolic left ventricular pressure did not change. Mean coronary arterial pressure and coronary vascular resistance distal to the stenosis significantly increased, while coronary blood flow through the stenosis tended to decrease. Intramyocardial pH tended to increase. Myocardial oxygen consumption significantly decreased. Cardiac sympathetic nerve stimulation after propranolol administration significantly increased mean aortic blood pressure, mean coronary arterial pressure and coronary vascular resistance distal to the stenosis. Coronary blood flow distal to the stenosis tended to increase. Intramyocardial pH did not change. These results suggest that propranolol appears to improve myocardial ischemia by decreasing myocardial oxygen consumption and increasing coronary perfusion pressure in the ischemic region, and that, even when in addition of cardiac sympathetic nerve stimulation, propranolol may not decrease coronary blood flow and prevent myocardial ischemia. |
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| Practice | Basic medicine |
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| Keywords | Sympathetic nerve stimulation, Propranolol, Myocardial Metabolism, Coronary Stenosis |
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