| Japanese |
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| Title | ラット摘出心における虚血時間と再灌流不整脈との関係 |
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| Subtitle | 原著 |
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| Authors | 楳田高士*, 田中一彦*, 中村正人**, 田倉学*, 泉貴文*, 末包慶太*, 古賀義久* |
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| Organization | *近畿大学医学部麻酔科学教室, **市立貝塚病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 15 |
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| Number | 3 |
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| Page | 430-436 |
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| Year/Month | 1994/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要約」虚血時間と再灌流不整脈との関係について検討した. ウイスターラット96匹(8群, 各群12匹)を用い, ランゲンドルフ法による冠灌流をクレブス液を用いて行なった. 左前下行枝の結紮, 解除により, 虚血および再灌流を行った. 虚血時間を5分, 10分, 11分, 12分, 13分, 15分, 20分, 30分の8群に分け, 再出流不整脈を検討した. 再灌流不整脈の観察時間としては再灌流撮, 3分間, 5分間, 10分間の各面とし, 検討した. 心室細動(VF)発現頻度は虚血時間10分群で75%, 11分〜15分群で100%, 20分群では92%, 30分群では17%と低下した. 観察時間(3分間)まで持続したsustained VF発現率は虚血時間11分群で92%をピークとするベル型を示し, VF持続時間についても虚血時間11分群をピークとする同様なベル型の曲線を示した. 再灌流不整脈の観察時間についての検討では再灌流後3分でのsustained VFの発現率と再灌流5分値の傾向が同じであり, またVF持続時間でも0-3分, 0-5分でほぼ同様な傾向を示した. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Reperfusion, Arrhythmia, Ventricular fibrillation, Ischemia |
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| English |
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| Title | The Effects of the Duraion of Preceding Ischemia on the Reperfusion-induced Arrhythmias in Isolated Perfused Rat Hearts |
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| Subtitle | Original article |
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| Authors | Takashi Umeda, Kazuhiko Tanaka, Masato Nakamura, Manabu Takura, Takafumi Izumi, Keita Suekane, Yoshihisa Koga |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Kinki University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 15 |
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| Number | 3 |
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| Page | 430-436 |
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| Year/Month | 1994/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」The effects of the duration of the preceding ischemia were investigated using isolated perfused rat hearts. Hearts (n=12 per group) were subjected to various times (0, 5, 10, 11, 12, 13, 15, 20, or 30 min) of regional ischemia induced by the occlusion of left anterior descending artery followed by 10 min of reperfusion. In 100% of hearts, VT occurred after more than 5 min of ischemia. The incidence of reperfusion-induced ventricular fibrillation (VF) was highest after 11-15 min of coronary artery occlusion (100%). With increasing and decreasing durations of ischemia, there were decreasing incidence of VF (after 10, 20, and 30 min of ischemia resulted in 75%, 92%, and 17% of the hearts exhibting VF respectively. The incidence of irreversible VF and the duration of VF were shown to have similar bellshaped time dependency curves with the peak at the duration of 11 min of ischemia and 3 min observation time. Observation times of 3, 5, 10 min after reperfusion for analysis of arrhythmia were investigated too. There were not remarkable changes during 3 groups. So 3 min observation time was enough for analysis of arrhythmia. We therefore concluded that a 11-min period of ischemia and 3 min observation time is appropriate in attempting to assess the ability of any agent to inhibit reperfusion arrhythmias in isolated perfused rat heart model. |
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| Practice | Basic medicine |
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| Keywords | Reperfusion, Arrhythmia, Ventricular fibrillation, Ischemia |
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