| English |
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| Title | Effects of Isoflurane Inhalation and Cardiac Sympathetic Nerve Stimulation on Myocardial Ischemia in the Canine Hearts with Severe Coronary Stenosis |
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| Subtitle | |
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| Authors | Arifumi Kohyama, Shozo Kaji, Satoshi Yasumoto*, Hideyuki Kimura, Hiroshi Kitahata, Takao Saito* |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology, Tokushima University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 15 |
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| Number | 4 |
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| Page | 570-578 |
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| Year/Month | 1994/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」The effects of isoflurane inhalation and cardiac sympathetic nerve stimulation on myocardial ischemia were studied in dogs with severe coronary artery stenosis (N=11). After institution of severe coronary artery stenosis in fentanyl anesthetized dog, 0.5mg・kg-1 propranolol was administered. Isoflurane was inhaled at the inspiratory concentration of 0.8%. Cardiac sympathetic nerve was stimulated electrically before and during isoflurane inhalation. By isoflurane inhalation, heart rate significantly increased, while left ventricular pressure, maximal rate of left ventricular pressure rise, and myocardial oxygen uptake decreased. Mean coronary artery pressure and coronary blood flow distal to the stenosis decreased and coronary vascular resistance distal to the stenosis tended to decrease. Aortic pressure decreased more than enlargement of pressure gradient of aorto-coronary artery distal to the stenosis. Intramyocardial pH in the inner layer of the ischemic region was decreased and myocardial lactate uptake ratio was worsened. With sympathetic nerve stimulation under isoflurane inhalation, mean coronary artery pressure and coronary blood flow increased and coronary vascular resistance tended to increase, while intramyocardial pH unchanged. These results suggest that isoflurane can dilate coronary artery distal to the stenosis and may induce the transmular steal. However, vasodilation of isoflurane may be weak to produce myocardial ischemia by coronary steal and myocardial ischemia during isoflurane inhalation may not occur in the absence of marked hemodynamic changes. |
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| Practice | Basic medicine |
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| Keywords | Isoflurane, Cardiac sympathetic nerve, Myocardial ischemia, Coronary stenosis. |
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