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| Title | Effects of Alpha Human Atrial Natriuretic Peptide on Cardiac Performance and Hormonal Responses in Anesthetized Beagles, and on Action Potential and Contractile Force in Guinea-Pig Papillary Muscles. |
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| Authors | Hiroshi Otsuka*, Osamu Kemmotsu*, Hisashi Sugimoto*, Takahisa Mayumi*, Fusazo Nakata*, Norio Inomata**, Takafumi Ishihara** |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology and lntensive Care, Hokkaido University School of Medicine, **Laboratory of Molecular Pharmacology, Suntory lnstitute for Biomedical Research |
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| Journal | Circulation Control |
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| Volume | 16 |
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| Number | 1 |
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| Page | 68-76 |
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| Year/Month | 1995/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」To evaluate usefulness of human atrial natriuretic peptide(hANP) in hypotensive anesthesia, we investigated the hemodynamic, hormonal changes and renal function in anesthetized beagles, Fifteen beagles were divided into three groups by infusion rate：0.5μg/kg/min (Group 1), 1μg/kg/min (Group 2), 3μg/kg/min (Group 3). The hANP was infused for 60 minutes then discontinued. Hypotensive values in steady-state were 84.1% (Group 1), 83.0% (Group 2) and 81.3% (Group 3) of the baseline levels, shown no significant differences. In the recovery period, systemic blood pressure (SBP) remained 88.7% (Group 1), 88.2% (Group 2) and 89.2% (Group 3) at 15min, followed by gradual recovery, HR and PAP did not change significantly throughout the study. On the other hand, cardiac output (CO) and left ventricular maximum dp/dt (LV dp/dt max) decreased gradually during the infusion period. And changes of systemic vascular resistance (SVR) and pulmonary vascular resistance (PVR) indicated no vasodilatory effects of hANP. Urine volume (UV) and creatinine clearance (Ccr) showed no significant increases during the infusion period. Hormonal values were not significantly altered by hANP infusion. Superfusion of hANP up to 1000 ng/ml, did not change any contractile variables of isolated guinea-pig cardiac muscles. Hypotension induced by hANP may be neither due to decreased afterload nor due to cardiac contractility. These data indicate that the hANP-induced hypotension which is accompanied with a reduction of CO and not followed by prompt recovery, may be restrained from clinical uses in humans. |
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| Practice | Basic medicine |
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| Keywords | Human atrial natriuretic peptide, lnduced hypotension, Hemodynamic effects, Hormonal effects, Cardiac contractility |
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