| Japanese |
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| Title | 終末呼気陽圧人工呼吸の臓器血液量に及ぼす影響 ―腹腔内圧と血管作動薬の影響― |
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| Subtitle | 原著 |
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| Authors | 福井明, 高折益彦, 木村健一, 藤田喜久 |
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| Authors(kana) | |
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| Organization | 川崎医科大学麻酔科学教室 |
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| Journal | 循環制御 |
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| Volume | 16 |
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| Number | 1 |
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| Page | 77-84 |
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| Year/Month | 1995/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」調節呼吸されたイヌで終末呼気陽圧(positive end-expiratory pressure：PEEP)呼吸を, さらにこれに腹腔内圧(intraabdominal pressure：IAP)を負荷した状態に血管作動薬を併用することにより循環血液量(circulating blood volume：CBV)ならびに臓器血液量(organ blood volume：OBV)がいかなる変化を受けるか検討した. Isosorbide dinitrate(ISDN)はPEEP, ならびにIAP負荷で上昇した平均右心房圧と平均門脈圧を減少させた. またdopamine(DOA)は平均動脈圧と心係数を上昇させた. しかし両血管作動薬ともPEEP負荷によって変化したCBVとOBVに影響を与えなかった. IAP負荷はPEEPによって生じた腹腔内OBVの増加, 胸腔内OBVの減少の程度を軽減したが, これに対する上記の血管作動薬の作用はほとんど認められなかった. すなわちPEEPによって生じる循環血液の体内血管分布は, DOAによって改善されることも, ISDNによって悪化されることも認められなかった. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Positive end-expiratory pressure (PEEP), Organ blood volume, Intraabdominal pressure, Radionuclide scintilating volumetnic method, Vasoactive drugs |
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| English |
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| Title | The Effect of Positive End-Expiratory Pressure on the Organ Blood Volume ―Attenuation by Vasoactive Drugs under Elavated Intraabdominal Pressure― |
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| Subtitle | |
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| Authors | Akira Fukui, Masuhiko Takaori, Kenichi Kimura, Yoshihisa Fujita |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Kawasaki Medical School |
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| Journal | Circulation Control |
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| Volume | 16 |
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| Number | 1 |
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| Page | 77-84 |
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| Year/Month | 1995/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We observed the effects of vasoactive drugs on the circulating blood volume as well as regional blood volume, such as the brain, intrathoracic organs, liver, spleen, and femoral skeletal muscles under 15 cm H2o positive end-expiratory pressure (PEEP) ventilation with or without intraabdominal pressure (IAP) of 20cm H2o loading on dogs. In the result, isosorbide dinitrate decreased the mean right atrial pressure and the mean portal venous pressure, which had been raised by PEEP and IAP loading. Dopamine increased the mean arterial pressure, cardiac output, and total peripheral vascular resistance. However, neither vasoactive drugs changed on the circulating blood volume or organ blood volumes, which had been changed by the PEEP loading. The increase in intraabdominal organ blood volumes and the decrease in intrathoracic organ blood volumes accompanied with PEEP were attenuated by IAP loading. However, the administration of these vasoactive drugs did not cause a further changes. In conclusion, the circulating blood volume distribution in the body caused by PEEP was neither improved by dopamine nor aggravated by isosorbide dinitrate. |
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| Practice | Basic medicine |
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| Keywords | Positive end-expiratory pressure (PEEP), Organ blood volume, Intraabdominal pressure, Radionuclide scintilating volumetnic method, Vasoactive drugs |
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