| Japanese |
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| Title | イヌ急性心不全モデルにおけるNKH477の血行動態に対する効果 |
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| Subtitle | 原著 |
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| Authors | 高平孝, 細野誠, 崎玉克彦 |
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| Organization | 日本化薬株式会社 医薬事業本部 総合研究所薬理研究室 |
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| Journal | 循環制御 |
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| Volume | 16 |
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| Number | 2 |
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| Page | 196-203 |
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| Year/Month | 1995/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」麻酔イヌを用いて急性心不全モデル(冠動脈結紮及び僧帽弁腱索切断)を作成し, NKH477の心血管系に対する作用を検討した. 冠結紮及び僧帽弁腱索切断によって, 左心房内圧(LAP)の上昇と心拍出量(CO)の減少が認められ, 心機能曲線は右下方へ移動した. また, 冠結紮モデルでは心筋組織血流量が虚血部で減少し, 正常部においてもわずかに減少した. これら2つの心不全モデルに対しNKH477(0.15〜0.6μg/kg/min)の持続静注は用量依存性にLAPを低下し, COを増加して心機能曲線を左上方へ移動させた. すなわちNKH477は, 上記心不全状態を改善させた. さらに冠結紮により減少した心筋組織血流量はNKH477により正常部では増加したが, 虚血部では維持されていた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | NKH477, Heart failure model, Hemodynamics, Acute myocardial infarction, Acute mitral regurgitation |
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| English |
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| Title | Cardiovascular effects of NKH477 in experimental canine heart failure |
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| Subtitle | |
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| Authors | Takashi Takahira, Makoto Hosono, Katuhiko Sakitama |
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| Authors(kana) | |
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| Organization | Pharmacology Section' Research Laboratories Pharmaceuticals Group' Nippon Kayaku Co., Ltd. |
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| Journal | Circulation Control |
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| Volume | 16 |
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| Number | 2 |
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| Page | 196-203 |
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| Year/Month | 1995/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We examined the cardiovascular effects of NKH477, a novel water-soluble forskolin derivative, in a model of acute heart failure caused by left circumflex artery ligation or chordal cut of the mitral valve in open-chest dogs anesthetized with pentobarbital. Ligation increased left atrial pressure (LAP) from 5.1±0.4 to 8.9±0.4 cm H2O(P<0.001) and decreased cardiac output (CO) from 1.3±0.1 to 1.1±0.1 L/min (P<0.001), myocardial blood flow (MCBF) in normal region from 78.2±4.6 to 61.9 ± 3.1 ml/min/100g (P<0.001) and ischemic region from 78.8±4.8 to 19.5±2.8 ml/min/100g (P<0.001). Intravenous infusion of 0.15μg/kg/min of NKH477 improved LAP to 6.9±0.5 cm H2O and CO to 1.4±0.1 L/min and increased MCBF in nomal region to 77.6±11.0 ml/min/100g, but not ischemic region. Chodal cut increased LAP from 4.7±0.4 to 14.7±0.9 cm H2O (P<0.001) and decreased CO from 1.5±0.1 to 1.3±0.1 L/min (P<0.001). Intravenous infusion of 0.15 μg/kg/min of NKH477 improved LAP to 10.6±1.6 cm H2O and CO te 1.7±0.2 L/min. These results show that intravenous infusion of NKH477 may have beneficial effects in acute heart failure following acute myocardial infarction or rupture of the chordae tendineae of the mitral valve. |
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| Practice | Basic medicine |
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| Keywords | NKH477, Heart failure model, Hemodynamics, Acute myocardial infarction, Acute mitral regurgitation |
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