Japanese
Title低酸素性アシドーシスへのNaHCO3投与が血中カテコラミン濃度に及ぼす影響
Subtitle原著
Authors神山有史, 富野泰子, 富野武人, 富山芳信, 加地省三, 木村英之, 北畑洋, 斎藤隆雄
Authors(kana)
Organization徳島大学医学部麻酔学教室
Journal循環制御
Volume16
Number2
Page204-211
Year/Month1995/
Article原著
Publisher日本循環制御医学会
Abstract「要旨」低酸素下アシドーシスに対するNaHCO3投与が血中カテコラミン濃度に及ぼす影響を雑種成犬にて検討した. (N=31) 低酸素吸入後血中エピネフリン(E), ノルエピネフリン(NE)は著明に上昇し, アシドーシスの進展と共にE及びNEは上昇した. NaHCO3の緩徐投与(100ml/hr)ではE及びNEは一定の傾向を示さなかった. 連続した2回の急速投与では1回目投与後E及びNEは低下傾向を, 2回目では1回目に比し上昇傾向を示した. 高張食塩水の急速投与では1回目E及びNEは一定の傾向を示さなかったが, 2回目は有意に上昇した. 血中E及びNE濃度は低酸素吸入, その後のアシドーシスの進展につれて上昇するが, 低酸素下ではアシドーシスより低酸素の影響の方が大きく, NaHCO3によるアシドーシス補正では血中E, NE濃度は低下し難いと思われる.
Practice基礎医学・関連科学
KeywordsNaHCO3, Epinephrine, Norepinephrine, Hypoxia
English
TitleEffects of NaHCO3 Infusion on Blood Epinephrine and Norepinephrine Levels during Hypoxia
Subtitle
AuthorsArifumi Kohyama, Yasuko Tomino, Taketo Tomino, Yoshinobu Tomiyama, Shozo Kaji, Hideyuki Kimura, Hiroshi Kitahata, Takao Saito
Authors(kana)
OrganizationDepartment of Anesthesiology, Tokushima University School of Medicine
JournalCirculation Control
Volume16
Number2
Page204-211
Year/Month1995/
ArticleOriginal article
PublisherJapan Society of Circulation Control
AbstractThe effects of NaHCO3 infusion on blood epinephrine (E) and norepinephrine (NE) levels during hypoxic metabolic acidosis induced by 2-hr inhalation of hypoxic gas (FIO2：9%) were studied in anesthetized dogs (N=31). After 2 hr of hypoxia, NaHCO3 was infused intravenously at a rate of 100 ml/hr in a dose of base excess × body weight × 0.2 mEq (the slow infusion group：N=12) or in 30 seconds with a half dose of slow NaHCO3 infusion group (the rapid infusion group：N=9). This treatment was repeated 5 min later in the rapid infusion group. One mole NaCl was infused rapidly during hypoxia in the same dose and same way as the rapid infusion group (NaCl group：N=10) and the responses were compared with that in the rapid infusion group. With inhalation of low fraction of oxygen, the blood levels of E and NE increased rapidly, then increased gradually as metabolic acidosis and hypoxemia proceeded (PaO2：22.0±2.9 mmHg, pH：7.169±0.097 at 2 hr after hypoxia). Reoxygenation after NaHCO3 infusion decreased blood E and NE levels significantly in the slow infusion group. Slow NaHCO3 infusion during hypoxia did not have a significant effect on blood E and NE levels although blood pH was improved. In 6 dogs of the rapid infusion group, E and NE with first infusion tended to decrease, but tended to increase with the second infusion. In rapid 1 mole NaCl infusion, E and NE levels had a tendency to increase with first infusion and significantly increased with the second infusion. These results suggest that NaHCO3 could decrease blood E and NE levels during hypoxia, but not effectively, and that the effect of hypoxemia on an increase in the blood E and NE levels may be stronger than that of acidosis.
PracticeBasic medicine
KeywordsNaHCO3, Epinephrine, Norepinephrine, Hypoxia

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