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| Title | Determinants for the Pressor Effect of Ephedrine in Awake or Anesthetized Humans：Effects of Age, General Anesthesia, or Basal Blood Pressure |
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| Subtitle | |
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| Authors | Toshiaki Nishikawa, Makoto Tanaka, Toshihiro Naganuma, Hiroshi Naito |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba. |
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| Journal | Circulation Control |
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| Volume | 16 |
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| Number | 2 |
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| Page | 212-217 |
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| Year/Month | 1995/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」To test the hypothesis that the pressor effect of ephedrine would be influenced by aging, general anesthesia, or basal blood pressure, we compared the pressor response to ephedrine in awake or anesthetized 103 patients, ranging in age from 13 to 82 yr. Hemodynamic measurements were made at 1-minute intervals for 10 minutes after ephedrine 0.1 mg・kg-1 was injected as a bolus in 30 awake patients. In the remaining 73 patients general anesthesia was induced with thiamylal 5 mg・kg-1 iv, and the trachea was intubated following vecuronium 0.2 mg・kg-1 iv. Anesthesia was maintained with enflurane 0.8-2.0% inspired and nitrous oxide 67% in oxygen, while the lungs were mechanically ventilated to maintain normocapnia. The same hemodynamic measurements were made at 1-minute intervals for 10 minutes after ephedrine 0.1 mg・kg-1. Although the pressor response to ephedrine was greater in anesthetized patients than awake patients, there was no relationship between age and maximal elevations in mean blood pressure following ephedrine in awake or anesthetized patients. Slight inverse correlations between the baseline values (before ephedrine injection) and the magnitude of maximal changes following ephedrine in mean blood pressure were noted in anesthetized (r=-0.57, P<0.001) and awake (r=-0.40, P<0.03) patients. It is concluded that the pressor responsiveness to intravenous ephedrine depends upon the baseline values and is augmented during enflurane/nitrous oxide anesthesia, but is not altered by aging. |
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| Practice | Basic medicine |
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| Keywords | Age, Ephedrine, General anesthesia, Pressor effect. |
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