| Japanese |
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| Title | ドパミン持続投与は麻酔による消化管酸素代謝異常を改善させるか |
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| Subtitle | 原著 |
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| Authors | 加藤敏文*, 小村好弘*, 森本裕二**, 森本佳子**, 太田善博**, 劔物修** |
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| Authors(kana) | |
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| Organization | *恵佑会札幌病院麻酔科, **北海道大学医学部麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 16 |
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| Number | 3 |
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| Page | 371-376 |
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| Year/Month | 1995/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」ASAクラス2ないし3の予定肝切除患者10名を対象として, イソフルラン麻酔(5名)またはイソフルランと胸部硬膜外併用麻酔(5名)中のドパミン2μg/kg/minの投与が胃粘膜内pH(pHi)の変化に与える影響を, ドパミン非投与群と比較検討した. pHiと血行動態値は対照値測定後30分毎に3回測定した. イソフルラン麻酔またはイソフルランと胸部硬膜外麻酔により低下したpHiは, ドパミン持続投与でcritical poinitとされる7.35以上に維持された. 肝切除術の麻酔中におけるドパミン投与の有用性が示唆された. 上腹部手術において手術操作や出血などによって消化管血流は低下しやすく, また麻酔法も消化管酸素代謝に大きな影響を与えるとされる1,2). 先に著者らは, 肝切除術を対象にして, イソフルラン麻酔及びイソフルランと胸部硬膜外併用麻酔の消化管酸素代謝に与える影響を検討し, 両麻酔法とも胃粘膜内pH(pHi)からみた消化管酸素代謝に大きな影響を与えることを明らかにした3). |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Isoflurane, Thoracic epidural anesthesia, Gastric intramucosal pH, Dopamine |
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| English |
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| Title | The Effect of General Anesthesia or Thoracic Epidural Anesthesia on the Gut Oxygenation ―Is the Gut Oxygenation Impaired by Dopamine Infusion? |
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| Authors | Toshihumi Kato*, Yuji Morimoto**, Yoshiko Morimoto**, Yoshihiro Ohta**, Yoshihiro Komura*, Osamu Kemmotsu** |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology, Keiyukai Sapporo Hospital, **Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 16 |
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| Number | 3 |
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| Page | 371-376 |
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| Year/Month | 1995/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | In this study, we evaluated the changes in the gastric intramucosal pH (pHi) as an index of gut oxygenation under the two anesthetic techniques with continuous dopamine infusion. The two anesthetic techniques was the general anesthesia by the inhaled anesthetics and the thoracic epidural anesthesia. Ten patients undergoing hepatic resection were randomly allocated into 2 groups：Isoflurane group or thoracic epidural anesthesia group. Anesthesia in the Isoflurane group was maintained with isoflurane and 60 % N2O in oxygen. In the epidural anesthesia group, bolus injection of 1.5 % lidocaine was initiated via T8-9 and then infusion of 1.5 % lidocaine continued under 60 % N2O in oxygen. The pHi and hemodynamic values were measured every 30 min until 90 min. In both groups, the pHi was maintained above the critical point (7.35), at which mortality was reported to increase in the ICU patients. Dopamine infusion was effective for maintenance of pHi in hepatic resection. (Circ Cont 16：371〜376, 1995) |
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| Practice | Basic medicine |
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| Keywords | Isoflurane, Thoracic epidural anesthesia, Gastric intramucosal pH, Dopamine |
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