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| Title | Comparative Hemodynamic Responses to Intravenous Ephedrine during Halothane, Enflurane, or Isoflurane Anesthesia |
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| Subtitle | |
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| Authors | Toshihiro Naganuma, Toshiaki Nishikawa, Harumi Nakayama, Yuichi Yaguchi, Hiroshi Naito |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba |
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| Journal | Circulation Control |
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| Volume | 16 |
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| Number | 4 |
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| Page | 533-537 |
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| Year/Month | 1995/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | uAbstractvSince the pressor effect of ephedrine is altered by various factors, this study was performed to evaluate the possible influences of volatile anesthetics. Hemodynamic responses to intravenous ephedrine were studied in ninety surgical patients who were randomly assigned to receive either halothane, enflurane, or isoflurane anesthesia. Blood pressure (BP) was measured oscillometrically, while heart rate (HR) was recorded by an electrocardiogram monitor. General anesthesia was induced with thiamylal 4-5 mgEkg-1 i. v. and tracheal intubation was facilitated with vecuronium 0.2 mgEkg-1 i. v. Thereafter, anesthesia was maintained with end-tidal concentration of halothane 0.3-1.0 %, enflurane 0.8-2.0 %, or isoflurane 0.5-1.5 % with 67 % nitrous oxide in oxygen to keep mean BP at approximately 90 % of preinduction values. Ventilation was controlled to maintain end-tidal carbon dioxide tension between 35-40 mmHg. After a stable hemodynamics was obtained, ephedrine 0.1 mgEkg-1 was injected intravenously as a bolus. BP and HR were recorded 1-minute intervals for ten minutes after ephedrine administration. The magnitudes of maximal increases in mean BP from baselines were similar among the three groups (15.7}8.4, 13.7}5.0, and 15.0}7.2 mmHg in patients anesthetized with halothane, enflurane, and isoflurane, respectively). There was also no difference in maximal HR increases (5.9}3.2, 6.2}4.5, and 5.9}4.7 beatsEmin-1 in patients anesthetized with halethane, enflurane, and isoflurane, respectively). It is concluded that a bolus injection of ephedrine 0.1 mgEkg-1 increased BP and HR similarly in anesthetized patients with halothane, enflurane or isoflurane. |
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| Practice | Basic medicine |
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| Keywords | Ephedrine, Enflurane, Halothane, Isoflurane, Blood pressure, Heart rate. |
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