| Japanese |
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| Title | 口腔内エピネフリン局所投与による終末呼気二酸化炭素分圧上昇の機序に関する研究 |
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| Subtitle | 原著 |
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| Authors | 菊田好則*, 岡田和夫*, 高崎正人*, 堀部原生*, 大川一美*, 湯川博美*, 菊地白** |
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| Authors(kana) | |
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| Organization | *帝京大学医学部麻酔学教室, **帝京大学医学部口腔外科学教室 |
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| Journal | 循環制御 |
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| Volume | 16 |
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| Number | 4 |
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| Page | 545-548 |
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| Year/Month | 1995/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」全身麻酔・調節呼吸下にエピネフリン(Ep)を口腔粘膜下に投与した時の終末呼気二酸化炭素分圧(PETCO2)上昇の機序に関して, ASAクラスIの口腔外科手術患者10名を対象に検討した. 呼吸・麻酔・代謝モニタにおいて, Ep1.2μg/kg投与で, PETCO2は10分後に対照値より5mmHg上昇し, 酸素摂取量は5分後に対照値より12%, 炭酸ガス排泄量は10分後に10%と共に増加した. ガス交換比は一定していた. 以上結果からEpによる代謝亢進が酸素消費量を増し, それに伴い二酸化炭素産生量が増加し, 換気量が一定であったためPETCO2が上昇したと考えられる. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Epinephrine, End-tidal carbon dioxide partial pressure, Oxygen consumption, Carbon dioxide output, General anesthesia |
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| English |
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| Title | Mechanism of the Increase of End-tidal Carbon Dioxide Partial Pressure after Submucosal Epinephrine Injection |
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| Subtitle | |
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| Authors | Yoshinori Kikuta*, Kazuo Okada*, Masahito Takasaki*, Motoo Horibe*, Kazumi Ohkawa*, Hiromi Yukawa*, Shiroshi Kikuchi** |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology, Teikyo University School of Medicine, **Department of Oral and Maxillofacial Surgery, Teikyo University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 16 |
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| Number | 4 |
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| Page | 545-548 |
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| Year/Month | 1995/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The mechanism underlying the increase of endtidal carbon dioxide partial pressure (PETCO2) when epinephrine (Ep) was injected submucosally under general anesthesia and controlled ventilation was studied in 10 oral surgical patients classified in class I of ASA. When 1.2 μg/kg of Ep was injected submucosally during monitoring of respiration and metabolism, PETCO2 increased by 5 mmHg over the control value 10 minutes after the injection. The oxygen consumption increased by 12 % over the control value 5 minutes after the injection and carbon dioxide output increased by 10 % over the control value 10 minutes after the injection, while the respiratory exchange ratio remained constant. From these results, it appears that PETCO2 increased due to the hypermetabolism induced by Ep, i. e. increase in oxygen consumption, which led to an increase in carbon dioxide production while the ventilation level remained constant. (Circ Cont 16：545〜548, 1995) |
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| Practice | Basic medicine |
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| Keywords | Epinephrine, End-tidal carbon dioxide partial pressure, Oxygen consumption, Carbon dioxide output, General anesthesia |
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