| Japanese |
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| Title | 内頚静脈血酸素飽和度と酸化型/還元型ヘモグロビン値におよぼすセボフルラン麻酔の影響 |
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| Subtitle | 原著 |
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| Authors | 亀井政孝, 大島孝, 唐沢富士夫, 佐藤哲雄 |
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| Authors(kana) | |
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| Organization | 防衛医科大学校麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 17 |
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| Number | 1 |
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| Page | 20-24 |
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| Year/Month | 1996/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」ASA1から2の患者8名を対象とし, 呼気終末セボフルラン濃度0.5MAC及び2.0MACにおける上内頚静脈球部酸素飽和度(Sjvo2)と近赤外線分析モニターより求めた酸化型及び還元型ヘモグロビン値を比較検討した. 呼気終末二酸化炭素濃度40mmHg前後, 平均動脈血圧は60mmHgから100mmHgに維持した. セボフルランの濃度を0.5MACから2.0MACに増加するに伴い, Sjvo2及び酸化型ヘモグロビン値は全ての症例で増加した. 還元型ヘモグロビン値は減少傾向を示し, 酸化型と還元型ヘモグロビン値の和は増加傾向を示した. 以上よりセボフルランは, 脳血管の拡張に伴う脳酸素運搬量の増加もしくは脳代謝の抑制に伴う脳酸素消費量の低下のいずれか, もしくは両者を惹起することが推察された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Cerebral blood flow, Cerebral metabolic rate for oxygen, Brain, Sevoflurane, Jugular bulb oxygen saturation, Near infrared spectroscopy. |
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| English |
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| Title | The Effects of Sevofiurane Anesthesia on the Jugular Bulb Oxygen Saturation and Oxygenated Hemoglobin Measured with Near-infrared Spectroscopy in Humans. |
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| Authors | Masataka Kamei, Takashi Ohshima, Fujio Karasawa, Tetsuo Sato |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, National Defense Medical College |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 1 |
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| Page | 20-24 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Although measurement of the jugular bulb oxygen saturation is an invasive method to monitor cerebral oxygenation, near infrared spectroscopy is a new, non-invasive method for cortical oxygenation because it enables us to evaluate oxygenated and deoxygenated hemoglobin. In this study, we compared oxygenated hemoglobin measured using near infrared spectroscopy with the jugular bulb oxygen saturation during sevoflurane anesthesia, and investigated the effects of sevoflurane on cerevral hemodynamics and metabolism in humans. Eight adult patients, undergoing gynecological or orthopedic surgery, were enrolled. No patient had either signs or symptoms of any cerebrovascular disease. Procedures were performed under epidural anesthesia combined with 0.5 or 2.0 MAC (minimal alveolar concentration) sevoflurane. Physioliogic variables such as PACO2, PaO2, blood pressure, hemoglobin, core temperature, and serum glucose level, changed very little throughout the period of observation. Ephedrine was administered intravenously to maintain arterial blood pressure. It was found that the jugular bulb oxygen saturation and oxygenated hemoglobin increased significantly when sevoflurane was increased from 0.5 to 2.0 MAC, but than deoxygenated hemoglobin had a tendency to decrease. Our results suggest that in humans sevoflurane may cause an increase in cerebral blood flow due to vasodilation, and/or a reduction in cerebral metabolic rate for oxygen. (Circ Cont 17：20〜24, 1996) |
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| Practice | Basic medicine |
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| Keywords | Cerebral blood flow, Cerebral metabolic rate for oxygen, Brain, Sevoflurane, Jugular bulb oxygen saturation, Near infrared spectroscopy. |
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