| Japanese |
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| Title | 経食道ドプラー心エコー法によるイヌの冠動脈狭窄における肺静脈血流波形の検討 |
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| Subtitle | 原著 |
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| Authors | 岩出宗代, 芦刈英理, 野村実, 杉野芳美, 鈴木英弘 |
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| Organization | 東京女子医科大学麻酔科学教室 |
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| Journal | 循環制御 |
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| Volume | 17 |
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| Number | 1 |
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| Page | 34-39 |
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| Year/Month | 1996/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」経食道ドプラー心エコー法を用いて, 急性心筋虚血時の肺静脈血流波形を検討した. 雑種イヌ7頭を対象とし, 笑気, 酸素, セボフルランで麻酔を維持し, 左冠動脈回旋枝の流量が対照の50%, 0%となるように狭窄を作成した. 各流量において, 収縮期血圧が一定になるようにセボフルラン濃度を調節した. 全例で局所壁運動異常を認めたが心拍出量は変化しなかった. また, 僧帽弁血流波形の各測定値には変化がなかったが肺静脈血流波形では収縮期波の減速度が有意に低下した. 本研究より肺静脈血流波形の変化が急性心筋虚血の早期の指標となる可能性が示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Pulmonary vein flow, Myocardial ischemia, Transesophageal echocardiography |
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| English |
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| Title | Pulmonary Vein Flow in Dogs with Coronary Artery Stenosis by Transesophageal Pulsed Doppler Echocardiography |
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| Subtitle | |
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| Authors | Motoyo Iwade, Eri Ashikari, Minoru Nomura, Yoshimi Sugino, Hidehiro Suzuki |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Tokyo Women's Medical College |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 1 |
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| Page | 34-39 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Progress in Doppler echocardiography and transesophageal echocardiography (TEE) has permitted the study of pulmonary vein (PV) flow. However, there have been no reports on PV flow in the presence of acute coronary stenosis. We examined the changes in PV flow in dogs with coronary artery stenosis. Seven mongrel dogs were anesthetized with nitrous oxide (50 %) -oxygen and sevoflurane. We produced left circumflex artery (LCX) stenosis by the occluder and maintained the blood flow by a flowmeter at three levels, i.e., the control state, 50 % flow and 0 % flow. We controlled the concentration of sevoflurane to maintain systolic blood pressure at 100 mmHg. 15 minutes after stenosis began, we measured hemodynamic variables and determined peak velocity, acceleration and deceleration in the early diastolic wave of mitral flow (E) and the systolic wave (S) or diastolic wave (D) of PV flow by using transesophageal Doppler echocardiography. We also measured fractional shortening on the short axis of left ventricle (LV). The concentration of sevoflurane needed to maintain systolic blood pressure was significantly reduced from 2.1±0.74 % at 100 % flow to 0.5±0.67 % at 0 % flow. Heart rate decreased and central venous pressure increased significantly at 0 % flow. Cardiac output did not change. In the Doppler variables, only deceleration in the S wave at 0 % flow showed a significant decrease from 2.24±1.04 % to 1.39±0.48 m/sec2. We found regional wall motion abnormalities (RWMA) in the posterior segments of the LV at 0 % flow in all dogs. Fractional shortening on the short axis of the LV was significantly reduced. Our stenotic model exhibited RWMA without global cardiac dysfunction, Under these conditions, only deceleration at the S wave of PV flow decreased significantly. This findings suggested that relaxation of the left atrium changed with myocardial ischemia, and therefore the E and D waves do not seems to be appropriate as indices of acute myocardial ischemia without cardiac dysfunction. (Circ Cont 17：34〜39, 1996) |
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| Practice | Basic medicine |
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| Keywords | Pulmonary vein flow, Myocardial ischemia, Transesophageal echocardiography |
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