| Japanese |
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| Title | 血圧変動時間からみた脳循環と大脳皮質組織酸素分圧の自己調節能 |
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| Subtitle | 原著 |
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| Authors | 百田義弘, 小谷順一郎, 安留輝之, 上田裕 |
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| Organization | 大阪歯科大学歯科麻酔学講座 |
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| Journal | 循環制御 |
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| Volume | 17 |
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| Number | 1 |
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| Page | 44-49 |
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| Year/Month | 1996/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」ラットを用いて, 体動脈圧を変動させた際の動脈圧―局所脳血流量関係と動脈圧―脳組織酸素分圧関係について, 血圧変動速度の面から検討を加えた. その結果, 局所脳血流量, 脳組織酸素分圧とも血圧変動に対する自己調節能を有するものの, 昇圧時には脳組織酸素分圧より局所脳血流量が, 降圧時には局所脳血流量より脳組織酸素分圧が, より大きく単位時間あたりの血圧変動量に依存して変化した. すなわち, 急峻な血圧下降時には, 脳酸素摂取率が増加するmisery perfusionの病態を示唆する所見を得たことから, 血圧変動速度によっては脳代謝予備能に影響を与えることが推察された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Autoregulation, Cerebral blood flow, Misery perfusion, Brain tissue partial oxygen pressure, Cerebral circulation. |
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| English |
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| Title | Effects of Systemic Blood Pressure on the Cerebral Circulation and Tissue Oxygen Autoregulation |
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| Authors | Yoshihiro Momota, Junichiro Kotani, Teruyuki Yasutome, Yutaka Ueda |
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| Organization | Department of Anesthesiology, Osaka Dental University |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 1 |
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| Page | 44-49 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Mean arterial blood pressure (MAP) -regional cerebral blood flow (r-CBF) relationship and MAP-brain tissue partial oxygen pressure (Pto2) relationship were evaluated accompanying changes in systemic arterial blood pressure in rats. Systemic arterial blood pressure was increased by infusion of phenylephrine and decreased by infusion of trimetaphan or blood withdrawal. Both r-CBF and Pto2 had the ability of autoregulation against changes in blood pressure, but, when blood pressure was increasing, changes in r-CBF rather than Pto2, and when blood pressure was decreasing, those in Pto2 rather than r-CBF, were more dependent on changes in blood pressure during a unit time period. When blood pressure was decreasing rapidly, findings suggestive of misery perfusion, in which the brain oxygen uptake rate is increased, were obtained. Therefore, the blood pressure change rate is considered to affect the cerebral metabolic reserve. (Circ Cont 17：44〜49, 1996) |
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| Practice | Basic medicine |
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| Keywords | Autoregulation, Cerebral blood flow, Misery perfusion, Brain tissue partial oxygen pressure, Cerebral circulation. |
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