| English |
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| Title | Interaction of Diltiazem and Volatile Anesthetics on Cardiac Function and Myocardial Metabolism in the Rat Heart-lung Preparation |
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| Subtitle | |
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| Authors | Masaki Kume, Satoshi Kashimoto, Kazumori Ikeya, Teruo Kumazawa |
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| Organization | Department of Anesthesiology, Yamanashi Medical University |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 1 |
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| Page | 50-56 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | uAbstractsvThe direct effects of diltiazem on cardiac function and myocardial metabolism in the presence of the volatile anesthetics halothane (H), enflurane (E), isoflurane (I) and sevoflurane (S) were assessed in the isolated heart|lung (H-L) preparation. Wistar-ST rats were randomly divided into 5 groups (each group n=8) as followsF1. Control (C) groupGdiltiazem (10-6M) with no volatile anesthetics. 2. The H groupGdiltiazem and 1 % halothane. 3. The E groupGdiltiazem and 2.2 % enflurane. 4. The I groupGdiltiazem and 1.5 % isoflurane. 5. The S groupGdiltiazem and 2.5 % sevoflurane. Five minutes after the start of perfusion on the H-L preparation, 10-6M of diltiazem was administered into the reservior. Thirty minutes after the start of perfusion, the hearts were freeze-clamped and myocardial ATP, ADP, AMP, lactate and glycogen were measured. Heart rate, cardiac output and LV dP/dt max in the E group decreased significantly by the administration of diltiazem. However, there were no significant differences in myocardial ATP, ADP, AMP, lactate and glycogen levels among the all groups. This result means that diltiazem under E has more cardiac depressant property than diltiazem under the other volatile anesthetics does, although diltiazem under all volatile anesthetics do not induce any deleterious effects on myocardial metabolism. |
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| Practice | Basic medicine |
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| Keywords | Diltiazem, Volatile anesthetics, Cardiac interaction, Myocardial metabolism |
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