| Japanese |
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| Title | ラット局所脳虚血病変への脳静脈還流障害の影響 |
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| Subtitle | 原著 |
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| Authors | 安留輝之 |
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| Authors(kana) | |
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| Organization | 大阪歯科大学歯科麻酔学講座 |
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| Journal | 循環制御 |
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| Volume | 17 |
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| Number | 1 |
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| Page | 57-64 |
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| Year/Month | 1996/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」局所脳虚血急性期における虚血病変や脳浮腫の進展に対する脳静脈還流障害の影響を, 高血圧自然発症ラットを用いて検討した. 脳静脈還流障害は両側外頸静脈遮断により作製し, 脳虚血は総頸動脈および中大脳動脈を遮断するモデルを用いた. その結果, 脳静脈還流障害単独では, 局所脳血流量, 脳組織酸素分圧に影響を与えることなく, 静脈性梗塞を発生させないが, 虚血性脳血管障害が合併した状況下では, 脳浮腫および梗塞巣を増大させた. 虚血進展に影響する最大因子である酸素供給の面から差を認めないにもかかわらず病変の悪化が観察された事実は, 軽度の脳静脈圧上昇でも, 虚血巣と周囲組織間の静水圧差拡大による脳水分含量の増加や血液脳関門の破綻が, 二次的に神経機能, 代謝に影響する可能性があることを示唆した. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Focal cerebral ischemia, Brain edema, Cerebral blood flow, Tissue oxygen pressure, Cerebral vein |
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| English |
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| Title | Effect of Impairment of the Cerebral Venous Return on Cerebral Focal Ischemic Lesions in Rats |
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| Subtitle | |
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| Authors | Teruyuki Yasutome |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Osaka Dental University |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 1 |
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| Page | 57-64 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Effect of impairment of the cerebral venous return by ligation of bilateral jugular veins on the progression of ischemic lesions and cerebral edema in the acute period of focal cerebral ischemia were evaluated in spontaneous hypertensive rats. A model of focal cerebral ischemia was prepared by ligation of the right common carotid artery and middle cerebral artery, and changes in the cerebral tissue oxygen pressure and regional cerebral blood flow during ischemia and reperfusion were studied. The severity of cerebral edema was evaluated by measuring the specific gravity and water content of the cerebral tissue. The results suggested that increases in the cerebral water content were due to an increase in the gradient of the static hydraulic pressure between the ischemic foci and surrounding tissues, and cerebral edema progressed in cerebral ischemia. These observations underline the importance of cerebral venous pressure in ischemic cerebrovascular disorders. (Circ Cont 17：57〜64, 1996) |
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| Practice | Basic medicine |
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| Keywords | Focal cerebral ischemia, Brain edema, Cerebral blood flow, Tissue oxygen pressure, Cerebral vein |
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