| Japanese |
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| Title | 低灌流肝の肝循環, 肝酸素代謝, 肝機能に及ぼすハロタン, エンフルランおよびイソフルランの影響 |
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| Subtitle | 原著 |
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| Authors | 水上智 |
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| Authors(kana) | |
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| Organization | 獨協医科大学越谷病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 17 |
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| Number | 1 |
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| Page | 65-72 |
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| Year/Month | 1996/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」イヌを使用して, 脱血とフェニレフリン投与による肝の低灌流時のエンフルランおよびイソフルラン麻酔による肝循環, 肝酸素需給動態, 肝機能の変化を, ハロタン麻酔を対照として比較した. その結果, (1)心拍出量, 門脈血流量, 総肝血流量, 肝酸素供給量はイソフルランで良く維持された. (2)肝酸素消費量, 供給量/消費量比もイソフルランで比較的良く維持される傾向が認められた. (3)ハロタン麻酔ではLDH, GOT, GPTが著明に上昇したのに対し, エンフルラン, イソフルラン麻酔では軽度上昇に止まった. 以上より, イソフルラン麻酔は肝の低灌流状態でも比較的よく肝循環, 肝酸素需給動態を維持し, 術後の肝障害を生じる危険性が少ないものと思われる. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Isoflurane, Enflurane, Halothane, Hypo-perfused liver |
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| English |
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| Title | Effects of Halothane, Enflurane or Isoflurane Anesthesia on Hepatic Circulation and Oxygen Metabolism of the Hypo-perfused Liver |
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| Subtitle | |
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| Authors | Satoshi Mizukami |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Koshigaya Hospital, Dokkyo University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 1 |
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| Page | 65-72 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Effects of halothane, enflurane or isoflurane anesthesia on the hypo-perfused liver, which was produced by bleeding and administration of phenylephrine, were studied in 26 mongrel dogs. Hepatic arterial and portal venous blood flows were measured by electromagnetic flowmetry. Hepatic oxygen metabolism was calculated from blood flows and oxygen contents of the hepatic artery, potal vein and hepatic vein. Cardiac output, potal venous blood flow, total hepatic blood flow and hepatic oxygen delivery were better maintained with isoflurane anesthesia, than halothane anesthesia. Also, isoflurane anesthesia seemed to maintain hepatic oxygen consumption, rather than halothane anesthesia. Serum LDH, GOT, and GPT were elevated remarkably higher with halothane anesthesia than enflurane or isoflurane anesthesia. These results suggest that halothane suppresses hepatic circulation and hepatic oxygen metabolism, and leads to serious hepatic dysfunction but enflurane or isoflurane doesnot, under hypo-perfused condition of the liver. (Circ Cont 17：65〜72, 1996) |
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| Practice | Basic medicine |
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| Keywords | Isoflurane, Enflurane, Halothane, Hypo-perfused liver |
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