| Japanese |
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| Title | プロスタグランジンE1投与が体外循環による血清N-acetyl-β-D-glucosamidase上昇に及ぼす影響 |
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| Subtitle | 原著 |
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| Authors | 富山芳信*, 平野禎造**, 多田文彦*, 細川滋俊*, 神山有史* |
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| Organization | *徳島大学医学部麻酔学教室, **高知市立市民病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 17 |
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| Number | 1 |
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| Page | 77-82 |
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| Year/Month | 1996/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」成人開心術症例においてプロスタグランジンE1(PGE1)を気管内挿管後から体外循環終了時まで20ng/kg/min, 体外循環終了後術後1日目まで10ng/kg/minで投与し, 体外循環による血清N-acetyl-β-D-glucosaminidase(NAG)の変化に及ぼすPGE1投与(PGE1群：N=10例)の影響を非投与群(N=10例)と比較検討した. 血清NAG値は血清蛋白で補正した値で評価した. 血清NAG値は両群とも大動脈遮断解除20分後より術前に比し有意に上昇し, 体外循環終了3−4時間後にピークを取った後低下したが, 術後3−4日目まで有意に高値を示し, 術後7日目に有意差のない値に低下した. 両群間にはいずれの時点でも有意な差はなかった. PGE120ng/kg/minの静脈内投与では体外循環中および体外循環後の血清NAG産生抑制作用は認められなかった. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Serum N-acetyl-beta-D-glucosaminidase, Cardiopulmonary bypass, Prostaglandin E1, White blood cell counts |
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| English |
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| Title | Effects of Prostaglandin E1 Infusion on Serum N-acetyl-β-D-glucosaminidase Level during and after Cardiopulmonary Bypass |
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| Authors | Yoshinobu Tomiyama, Teizo Hirano*, Fumihiko Tada, Shigetoshi Hosokawa, Arifumi Kohyama |
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| Organization | Department of Anesthesiology, Tokushima University School of Medicine, *Department of Anesthesiology, Kochi Municipal Hospital |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 1 |
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| Page | 77-82 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We studied the effects of prostaglandin E1 (PGE1) infusion on serum N-acetyl-β-D-glucosaminidase (NAG) level during and after cardiopulmonary bypass in 20 adult patients undergoing cardiac surgery. These patients were divided into two groups：control group (n=10) and PGE1 group (n=10). In PGE1 group, PGE1 was infused intravenously at the rate of 20 ng/kg/min after endotracheal intubation to the end of CPB and 10 ng/kg/min after CPB until first postoperative day. Serum NAG levels were measured before induction of anesthesia, during CPB (30 min after initiation of CPB and 20 min after aortic declamping) and after CPB (15 min and 3-4 hr after termination of CPB and 1st, 3-4th and 7th postoperative day). In both groups, serum NAG levels increased after aortic declamping and peaked at 3-4 hr after termination of CPB, then decreased gradually. These values showed no significant difference between two groups in serum NAG levels during and after CPB. We conclude that the infusion of PGE1 at the rate of 20 ng/kg/min could not inhibit the increase of serum NAG level. (Circ Cont 17：77〜82, 1996) |
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| Practice | Basic medicine |
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| Keywords | Serum N-acetyl-beta-D-glucosaminidase, Cardiopulmonary bypass, Prostaglandin E1, White blood cell counts |
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