| Japanese |
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| Title | 完全人工心臓の自動制御関数(1/R制御)の開心術後血行動態予測制御に向けての検討 |
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| Subtitle | 原著 |
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| Authors | 今西薫***, 阿部裕輔*, 井街宏*, 須田優司***, 鎮西恒雄*, 満渕邦彦**, 藤正巌**, 小山雄次***, 須磨幸蔵*** |
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| Authors(kana) | |
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| Organization | *東京大学医学部医用電子研究施設, **東京大学先端科学技術研究センター, ***東京女子医科大学附属第2病院心臓血管外科 |
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| Journal | 循環制御 |
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| Volume | 17 |
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| Number | 2 |
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| Page | 204-208 |
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| Year/Month | 1996/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」本研究は, 東京大学医学部医用電子研施設で開発された完全人工心臓の自動制御法(1/R制御)が, 開心術後の患者の血行動態の予測制御に適用可能であるかを検討することを目的とした. 対象は東京女子医科大学附属第2病院心臓血管外科および関連施設で採取した臨床例12例のデータ79ポイントを対象とした. 1/R制御関数をヤギのデータ入力用から臨床データ入力用に変更するため, 1/R制御関数の補正項の係数を0.04, 0.06と設定変更した. 上記制御関数を用いて予想心拍出量を求め実測心拍出量との相関関係を検討した. 予想心拍出量と実測心拍出量との回帰分析の結果は統計学的に有意な相関関係(P<0.001)を認めた. 以上より1/R制御関数は臨床の現場で血行動態の予測制御への適用の可能性が示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Circulation control, Peripheral vascular resistance, Total artificial heart, Cardiac output, 1/R control method |
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| English |
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| Title | Clinical Application of Reciprocal of Peripheral Vascular Resistance(1/R) Control Method for Circulation Control of Severe Heart Failure Patients |
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| Authors | Kaoru Imanishi**, Yusuke Abe, Kou Imachi, Yuji Suda**, Tsuneo Chinzei, Kunihiko Mabuchi*, Iwao Fujimasa**, Yujj Koyama**, Kozo Suma** |
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| Organization | Institute of Medical Electronics, Faculty of Medicine, University of Tokyo, *Researeh Center for Advanced Science and Technology, University of Tokyo, **Department of Cardiovascular Surgery, Tokyo Women's Medical College Daini Hospital |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 2 |
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| Page | 204-208 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Total artificial heart is now widely used in the clinical field as a bridge to cardiac transplantation or circulatory assistance for the cases of post cardiotomy cardiogenic shock. There are several types of control method of total artificial heart. However, no physiological control method of total artificial heart exists. Abe, et al in our institute, found that the peripheral vascular resistance (R) reflects the signal from the cardiovascular center. Therefore, the reciprocal of the peripheral vascular resistance (1/R) is used as a function to determine the cardiac output. The 1/R control method of total artificial heart was contifirmed. The final control function by Abe, et al is shown in the following equation. CO=(AoP. set(n)-RAP. set(n)) CO meas./(Aop-RAP)+CP(Aop-Aop. set(n)), where CO is target cardiac output (l/min.), Aop. set(n) is setting point of the Aop (100 mmHg), RAP. set(n) is setting point of the RAP (8 mmHg), CO meas is measured cardiac output, and CP is the gain of the correction (0.04 or 0.06). The evaluation of this function was performed in the Department of Cardiovascular Surgery of Tokyo Women's Medical College Daini Hospital. Seventy-nine hemodynamic data points from twelve patients underwent coronary artery bypass grafting (CABG) were used. Target cardiac output was calculated using this control function equation. Significant correlation between target cardiac output and calculated cardiac output was observed (p<0.001). These results indicate that the 1/R control function can be applicable as the hemodynamic control method for the severe heart failure patients. (Circ Cont 17：204〜208, 1996) |
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| Practice | Basic medicine |
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| Keywords | Circulation control, Peripheral vascular resistance, Total artificial heart, Cardiac output, 1/R control method |
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