| English |
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| Title | Effects of Ketamine on Intracellular Free Calcium in Bovine Carotid Artery Endothelial Cells |
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| Subtitle | |
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| Authors | Keigo Sugiki, Kiyoshi Shakunaga, Koji Jomura, Yusuke Ito |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 2 |
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| Page | 209-213 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」We focused on endothelium-mediated vasodilation as a mechanism of the vasodilatory effects of ketamine. Cultured bovine carotid artery endothelial cells were loaded with the Ca2+ indicator dye：fluo3, and intracellular Ca2+ levels of the endothelial cells were monitored by a confocal laser-scanning microscope. After application of ketamine in final concentrations of 10-5-10-3M, intracelfular Ca2+ levels were increased in a concentration-dependent manner. Our findings suggest that the Ca2+ -dependent production and/or release of vasodilator substances in the endothelium contributes, at least in part, to ketamine-induced vasodilation. |
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| Practice | Basic medicine |
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| Keywords | Ketamine, Endothelial cell, Intracellular free calcium, Fluo3, Confocal laser-scanning microscope |
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