| Japanese |
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| Title | ACE阻害剤(カプトプリル)の昇圧抑制機序の検討―アンギオテンシンII受容体遮断剤との対比― |
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| Subtitle | 原著 |
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| Authors | 湊口信也*, 伊藤裕康**, 横山仁美*, 今井洋子*, 越路正敏*, 各務雅夫*, 宇野嘉弘*, 藤原久義* |
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| Authors(kana) | |
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| Organization | *岐阜大学医学部第2内科, **澤田病院 |
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| Journal | 循環制御 |
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| Volume | 17 |
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| Number | 2 |
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| Page | 223-229 |
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| Year/Month | 1996/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」［目的］カプトプリル(CAP)の昇圧抑制機序を検討するため, (1)交感神経末端アンギオテンシン(ANG)II受容体を介するノルエピネフリン(NE)遊離抑制作用と(2)NEに対する血管収縮抑制効果をANG II受容体遮断剤(ロサルタン, LOS)と比較した. ［方法］pithed ratを用い, CAP(1mg/kg)とLOS(1mg/kg)投与前後で, (1)腰部交感神経電気刺激(SNS)直後の血漿NE濃度を測定, (2)各用量のNE静注による血圧上昇量, また, (3)各頻度のSNSによる血圧上昇量を求めた. ［結果］(1)CAPとLOSはSNSによる血漿NE濃度の上昇を有意に抑制した. (2)CAPはNEによる用量−血圧反応曲線を有意に抑制したが, LOSは影響を与えなかった. (3)LOSにCAPを重ね投与した後の頻度−血圧反応曲線はLOS単独の曲線に比べ, さらに強く抑制されたが, LOSをCAPに重ね投与した後の曲線は, CAP単独投与に比べ, 有意に抑制されなかった. ［結論］CAPの昇圧抑制機序の一部は, (1)交感神経末端からのNE遊離抑制と, (2)NEによる“血管収縮抑制”作用であることが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Captopril, Losartan, Norepinephrine, Angiotensin II receptor, Pithed rat |
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| English |
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| Title | The Mechanism for Inhibiting Effect of ACE inhibitor (Captopril) on the Pressor Response ―A Comparison with an Angiotensin II Receptor Antagonist― |
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| Authors | Shinya Minatoguchi, Hiroyasu Ito*, Hitomi Yokoyama, Yoko Imai, Masatoshi Koshiji, Masao Kakami, Yoshihiro Uno, Hisayoshi Fujiwara |
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| Authors(kana) | |
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| Organization | 2nd Department of Internal Medicine, Gifu University School of Medicine, *Sawada Hospital |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 2 |
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| Page | 223-229 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We investigated the mechanism for inhibiting effect of captopril on the pressor responses, by comparing with losartan. Plasma norepinephrine concentrations were measured during the sympathetic nerve stimulation (SNS, 2 Hz, 1 msec, 60 sec) before and after the administration of captopril (1 mg/kg, i.v.) or losartan (1 mg/kg, i.v.). The pressor responses to exogenous norepinephrine were obtained before and after the administration of captopril (1 mg/kg, i.v.) or losartan (1 mg/kg, i.v.). The pressor responses to SNS before and after the administration of losartan (1 mg/kg, i.v.) with additive treatment with captopril (1 mg/kg, i.v.) or captopril (1 mg/kg, i.v.) with additive treatment with losartan (1 mg/kg, i.v.). Both captopril and losartan significantly decreased plasma norepinephrine concentration. Dose-response curves to i.v. administration of norepinephrine were not altered by losartan, but were significantly decreased by captopril. Captopril and losartan (1 mg/kg) decreased the frequency-response curves to a similar extent. The additive treatment with captopril to losartan further decreased the curves. However, the additive treatment with losartan to captopril did not alter the curves. It is suggested that captopril decreases the pressor responses to SNS by both norepinephrine release inhibiting effect and decreasing “vascular reactivity” to norepinephrine. (Circ Cont 17：223〜229, 1996) |
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| Practice | Basic medicine |
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| Keywords | Captopril, Losartan, Norepinephrine, Angiotensin II receptor, Pithed rat |
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