| English |
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| Title | The Effects of Dopamine and Nitroglycerin on the Size of Myocardial Ischemic Area in Dogs under Isoflurane Anesthesia ―A Thermographic Study― |
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| Subtitle | |
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| Authors | Sho Yokota, Takehiko Ishikawa, Tsutomu Enya, Chizuko Takigawa, Takahisa Mayumi, Osamu Kemmotsu |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 3 |
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| Page | 390-397 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」A computerized experimental system is described that can visually display and quantify the size of the inchemic area of a beating heart using thermography. The ischemic area defined by this system is termed Thermographically Determined Myocardial Ischemic Area (TDMIA). This system includes monitoring and filing of heart rate, arterial pressure, cardiac output, end-tidal CO2, anesthetic gas concentrations and temperatures. We have used the system to evaluate the effects of nitroglycerin and dopamine on cardiac function and coronary blood flow during ischemia. Nitroglycerin alone (0.5μg/kg/min and 1μg/kg/min) had no effect on TDMIA compared to control dogs. Nitroglycerin at 1 μg/kg/min with dopamine at 7.5 μg/kg/min significantly decreased TDMIA (vs. Baseline；P=0.002, vs. Control Group；p=0.046). Dopamine alone 7.5 μg/kg/min had the similar effect on TDMIA (vs. Baseline；p=0.0016, vs. Control Group；p=0.039). We speculated that dopamine increased the coronary flow of the ischemic area in this experimental model. We conclude that dopamine may have beneficial effects on myocardial ischemic area in the early phase of acute myocardial infarction in the canine model. |
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| Practice | Basic medicine |
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| Keywords | Heart：myocardial ischemia；coronary blood flow, Pharmacology：nitroglycerin；dopamine, Thermography |
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