| Japanese |
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| Title | 冠動脈再建術におけるアムリノンの血行動態, 肺ガス交換能への影響 |
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| Subtitle | 原著 |
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| Authors | 立花千秋 |
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| Authors(kana) | |
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| Organization | 東京女子医科大学附属第2病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 17 |
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| Number | 3 |
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| Page | 398-405 |
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| Year/Month | 1996/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」本研究は, 冠動脈再建術(CABG)におけるカテコラミン投与量減量を目的として人工心肺(CPB)内に投与されたアムリノンの血行動態と肺ガス交換能に対する影響を, CPB離脱直前のCPB回路内にアムリノン2mg・kg-1を投与したA群と投与しなかったC群で比較した. 各パラメーターの測定は麻酔導入後とCPB離脱後15分, 30分, 60分, 90分に行った. CIは90分でA群がC群より高値を示した. SVRI, PVRIは15分と90分でA群がC群より低値を示した. SVIは両群間では差がなかったが, A群で麻酔導入後に比べCPB後有意に増加した. A−aDo2は60分以降で, QS/QTは30分以降で, A群がC群より高値を示した. PaO2は90分でA群がC群より低値を示した. CPB後のカテコラミン投与量は両群間に差がなかった. A群でのアムリノン血中濃度は, CPB回路血の返血により90分後でも最小有効血中濃度の1μg・ml-1以上を保持していた. CPB離脱時のアムリノン投与は, 離脱後のカテコラミン投与量減量はできなかったが, 血行動態の安定に有用であった. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Amrinone, Hemodynamic, Pulmonary Gasexchange, Cardiac Surgery |
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| English |
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| Title | Effects of Amrinone on Hemodynamics and Pulmonary Gas Exchange during Cardiac Surgery |
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| Subtitle | |
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| Authors | Chiaki Tachibana |
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| Organization | Tokyo Women's Medical College Daini Hospital |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 3 |
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| Page | 398-405 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The purpose of the present study was to examine the effects of amrinone on hemodynamics and pulmonary gas exchange during cardiac surgery Twenty-four patients undergoing aortocoronary bypass grafting were studied. Patients received either amrinone (2mg・kg-1 bolus dose before separation from CPB：group A, n=12) or nothing (control：group C, n=12) in a random single blinded fashion. The patients were anesthetized with fentanyl. midazolam, isoflurane/nitrous oxide and pancuronium. Patients end-expiratory Pco2 was maintained at about 30 mmHg. Oxygenation and hemodynamic variables were evaluated five times：after the induction of the anesthesia (baseline), 15, 30, 60, and 90 min after weaning from CPB. The values of the two groups were compared. During the study. patients were ventilated with oxygen (FIO2=1.0). There was no significant difference between the demographic data and baseline data of groups A and C. Cardiac index at 90 min in group A was significantly higher than those in group C. Systemic vascular resistance index and pulmonary vascular resistance index at 15 and 90 min in group A were significantly lower than those in group C. Alveolar arterial oxygen difference at 60 and 90 min. pulmonary shunt at 30, 60 and 90 min in group A were significantly higher than those in group C. There was no difference in the oxygen supply/demand balance between the two groups. Amrinone was effective to facilitate weaning from CPB, but it increased pulmonary shunt. (Circ Cont 17：398〜405, 1996) |
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| Practice | Basic medicine |
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| Keywords | Amrinone, Hemodynamic, Pulmonary Gasexchange, Cardiac Surgery |
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