| Japanese |
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| Title | 冠動脈狭窄イヌにおける大動脈遮断時のニトロプルシッドの血行動態に及ぼす影響 |
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| Subtitle | 原著 |
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| Authors | 長沢千奈美, 野村実, 小高桂子, 河合典子, 野村ゆう子, 三浦芳則, 鈴木英弘 |
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| Organization | 東京女子医科大学麻酔科学教室 |
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| Journal | 循環制御 |
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| Volume | 17 |
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| Number | 4 |
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| Page | 566-573 |
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| Year/Month | 1996/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」今回は, 虚血性心疾患における, ニトロプルシッド(SNP)の安全性の評価を目的として実験的に冠動脈狭窄イヌを作製し, 胸部下行大動脈遮断時の血圧上昇に対して, SNPが循環動態, 心筋代謝, 及び心筋組織血流量に及ぼす影響を検討した. SNPは大動脈遮断後の血圧上昇に対して, 速やかな降圧作用を示し, 心拍出量及び左室dp/dtを有意に増加させ, 冠動脈血流量, 心筋組織血流量も良好に維持した. 心筋代謝の面では, 心筋酸素摂取率は有意に低下した. 以上よりSNPは速やかな血管拡張作用を示し, 心筋酸素摂取率を有意に低下することにより心筋酸素需給バランスを保ち, 虚血性心疾患の大動脈遮断時の血管拡張薬として有用であることが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Nitroprusside, Coronary constricted dogs, Aortic cross-clamping. |
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| English |
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| Title | Nitroprusside Improves Myocardial Oxygen Balance during Descending Aortic Cross-clamping in Experimentally Coronary Constricted Dogs. |
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| Authors | Chinami Nagasawa, Minoru Nomura, Keiko Kodaka, Noriko Kawai, Yuko Nomura, Yoshinori Miura, Hidehiro Suzuki |
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| Authors(kana) | |
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| Organization | Department of anesthesiology, Tokyo Women's Medical College |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 4 |
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| Page | 566-573 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We investigated the hemodynamic effects of nitroprusside during cross-clamp of the descending aorta in experimentally coronary constricted dogs. Using 16 adult mongrel dogs, coronary constriction was produced by reducing 50 % of the left anterior descending coronary arterial blood flow. After stabilization of hemodynamics, we cross-clamped the descending aorta and administered nitroprusside (10μg/kg/min). The drug was infused for 15 minutes and was discontinued just before the clamp on the aorta was released. The cardiac output (CO) increased 42 % and left ventricular dp/dt (LV dp/dt) increased 43% significantly, compared with preclamping values. The myocardial blood flow (MBF) in ischemic area, measured by hydrogen clearance method, significantly increased 39% and the value of the myocardial oxygen extraction ratio (MO2 ext) decreased 12% compared with pre-clamping values. The results suggest that nitroprusside improves the cardiac depressant effects due to aortic cross-clamping in these experimentally coronary constricted dogs, but with regard to maintaining the MBF and the metabolism, nitroprusside appears to be the better choice for blood pressure control. (Circ Cont 17：566〜573, 1996) |
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| Practice | Basic medicine |
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| Keywords | Nitroprusside, Coronary constricted dogs, Aortic cross-clamping. |
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