| Japanese |
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| Title | プロポフォールによる麻酔導入が循環動態に与える影響 |
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| Subtitle | 原著 |
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| Authors | 山森祐治*, 斉藤洋司*, 豊田浩作**, 坂口泰子**, 小坂義弘* |
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| Authors(kana) | |
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| Organization | *島根医科大学附属病院集中治療部, **島根医科大学麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 18 |
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| Number | 1 |
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| Page | 20-23 |
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| Year/Month | 1997/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」予定手術患者15名を対象とし, プロポフォール2mg/kgの単回投与に続く10mg/kg/hrの持続投与による麻酔導入時の循環動態変化を, 胸郭インピーダンス法を用いて連続的に測定した. 心拍出量(CO)は導入後経時的に減少し, 2分後で-13.3%, 4分後で-19.7%, 5分後で-14.5%と有意に減少し, 挿管直後には前値に回復したものの, その後再び減少した. 一回拍出量及び血圧もほぼCOと同様の変化を示した. 心拍数は導入後及び挿管後もほとんど変化は認められなかった. プロポフォールによる麻酔導入により循環が抑制されることが確認され, その使用にあたっては注意を要すると思われた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Propofol, Hemodynamic effect, Thoracic bioimpedance |
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| English |
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| Title | Hemodynamic Effects of Anesthesia Induction with Propofol |
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| Subtitle | |
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| Authors | Yuji Yamamori*, Yoji Saito*, Kousaku Toyoda**, Yasuko Sakaguchi**, Yoshihiro Kosaka* |
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| Authors(kana) | |
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| Organization | *Intensive Care Unit, Shimane Medical University, **Department of Anesthesiology, Shimane Medical University |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 1 |
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| Page | 20-23 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The hemodynamic effects of propofol, given as a single dose of 2mg・kg-1 followed by a continuous infusion of 10 mg・kg-1・h-1, were studied in 15 patients scheduled for elective surgery. Blood pressure (BP) was measured using an automatic oscillometric technique, heart rate (HR) was derived from ECG, and cardiac output (CO) and stroke volume (SV) were measured with a thoracic bioimpedance method. Propofol significantly decreased CO by 13.3%, 19.7% and 15.4% in one, two and three minutes after induction, respectively. CO returned to the baseline value immediately by intubation and again significantly decreased from 2 and 5 minutes after intubation. Similar changes were observed in BP and SV. HR was not altered throughout the procedure. It is concluded that anesthesia induction with propofol induces hemodynamic depression. This study suggests that a particular caution should be taken when propofol is used for induction in patients with the impaired cardiovascular system. (Circ Cont 18：20〜23, 1997) |
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| Practice | Basic medicine |
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| Keywords | Propofol, Hemodynamic effect, Thoracic bioimpedance |
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