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| Title | Calcium Antagonists Depress Cardiac Function after Coronary Ligation in Rats. |
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| Subtitle | |
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| Authors | Satoshi Kashimoto, Masaki Kume, Kazumori Ikeya, Takeshi Oguchi, Teruo Kumazawa |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Yamanashi Medical University |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 1 |
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| Page | 24-29 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」Calcium antagonists are currently approved for use in patients with arrhythmias, stable and unstable angina pectoris, and systemic hypertension. However, the effects of calcium antagonists upon the outcome of experimental or clinical myocardial infarction are still debated. We evaluated the effects of calcium antagonists on the isolated perfused rat heart which coronary was ligated. Forty four isolated rat heart-lung preparations from male Wistar rats weighing 300-320 g were randomly divided into 4 groups according to the used drug as follows：1. Control (C) group； no drug. 2. Diltiazem (D) group；4x10-7M of diltiazem. 3. Nicardipne (N) group；100ng/ml of nicardipine. 4. Verapamil (V) group；3x10-7M of verapamil. The left anterior descending coronary artery was ligated and one of calcium antagonists was administered 8 min and 13 min after the start of perfusion, respectively. Thirty min after the perfusion, the heart was divided into infarcted and non-infarcted regions and freeze-dried for 6 days. Myocardial high energy phosphates (ATP, ADP and AMP) were measured by the high performance liquid chromatography. Myocardial lactate (L) and pyruvate (P) were measured by the enzymatic method. Coronary ligation did not influence hemodynamics in all groups, but verapamil decreased cardiac output and left ventricular (LV) dP/dt max significantly in the coronary ligated heart. There was no significant difference in the weights of infarcted regions produced by ligation among the groups. However, the weight of infarcted region in the V group was heavier than that of non-infarcted region. In all groups, myocardial ATP levels in infarcted regions were significantly lower than those in non-infarcted regions. In addition, myocardial ADP, AMP levels and L/P ratio in infarcted regions were significantly higher than those in non-infarcted regions. However, there were no significant differences in high energy phosphates levels and L/P ratio among the groups. Although all calcium antagonists did not influence the metabolism in the infarcted heart, they, especially verapamil, caused LV depression. This may support the clinical impression that most of calcium antagonists available are not clearly safe in patients with myocardial infarction. |
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| Practice | Basic medicine |
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| Keywords | Calcium antagonists, Myocardial infarction, Myocardial metabolism. |
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