| Japanese |
|---|
| Title | フェンタニール麻酔イヌにおける一酸化窒素合成阻害薬(NG-nitro-L-arginine-methyl ester)の左室収縮能および弛緩能の抑制 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 羽染直樹, 光畑裕正, 斉藤仁, 竹内晴彦, 清水禮壽 |
|---|
| Authors(kana) | |
|---|
| Organization | 自治医科大学麻酔科学教室 |
|---|
| Journal | 循環制御 |
|---|
| Volume | 18 |
|---|
| Number | 1 |
|---|
| Page | 30-35 |
|---|
| Year/Month | 1997/ |
|---|
| Article | 原著 |
|---|
| Publisher | 日本循環制御医学会 |
|---|
| Abstract | 「要旨」一酸化窒素(NO)は循環器系の生理的調節機能において重要な役割を果たしている. NO合成酵素阻害薬NG-nitro-L-arginine-methyl ester(L-NAME)を60mg・kg-1投与したときのフェンタニール麻酔イヌでの左室機能について検討した. 左室収縮能, 弛緩能の指標はそれぞれ左心内圧の上昇率の正の最大値(dP/dtmax), 左室等容拡張期の心内圧変化の時定数Tを用いた. 平均動脈圧が有意に上昇し, 心拍出量及び一回拍出量は有意に低下した. (dP/dtmax/平均動脈圧)は投与30分後, 時定数Tは90分後に有意に抑制された. L-NAMEは左室収縮能および左室弛緩能を抑制した. |
|---|
| Practice | 基礎医学・関連科学 |
|---|
| Keywords | NG-nitro-L-arginine-methyl ester, Fentanyl, The time constant, dP/dtmax |
|---|
| English |
|---|
| Title | A Nitric Oxide Synthase Inhibitor, NG-nitro L-arginine-methyl ester, Inhibits Left Ventriclar Systolic and Diastolic Function in Fentanyl-anesthetized Dogs |
|---|
| Subtitle | |
|---|
| Authors | Naoki Hasome, Hiromasa Mitsuhata, Jin Saitoh, Haruhiko Takeuchi, Reiju Shimizu |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Anesthesiology, Jichi Medical School |
|---|
| Journal | Circulation Control |
|---|
| Volume | 18 |
|---|
| Number | 1 |
|---|
| Page | 30-35 |
|---|
| Year/Month | 1997/ |
|---|
| Article | Original article |
|---|
| Publisher | Japan Society of Circulation Control |
|---|
| Abstract | Nitric oxide (NO), synthesized from the terminal guanidino nitrogen atom of L-arginine by a constitutive nitric oxide synthase in vascular endothelial cells, plays an important role in the physiological regulation of blood flow and blood pressure. We assessed the effect of a nitric oxide synthase inhibitor, NG-nitro-L-arginine-methyl ester (L-NAME), on left ventricular (LV) systolic and diastolic function in fentanyl-anesthetized dogs. The maximum rate of rise of LV pressure (dP/dtmax) and the time constant of the fall of isovolumic LV pressure (T) were measured as indices of LV systolic function and diastolic function, respectively. T is the inverse negative of the slope of the line obtained by plotting the natural logarithm of the fall in LV pressure beginning at maximum negative dP/dt to the level of LV end-diastolic pressure against time. L-NAME significantly increased mean arterial pressure (MAP) and significantly decreased cardiac output and stroke volume. L-NAME significantly inhibited dP/dtmax/MAP (To correct the effects of afterload on dP/dt, the variable was calculated as dP/dtmax divided by MAP) at 30 min, and significantly increased T at 90 min after the administration. In conclusion, L-NAME depresses both LV systolic and diastolic function in fentanyl-anesthetized dogs. (Circ Cont 18：30〜35, 1997) |
|---|
| Practice | Basic medicine |
|---|
| Keywords | NG-nitro-L-arginine-methyl ester, Fentanyl, The time constant, dP/dtmax |
|---|