| English |
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| Title | Effect of Prostaglandin E1 on Plasma Lidocaine Concentrations during Epidural Block |
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| Subtitle | |
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| Authors | Masayasu Nakayama, Hikaru Inoue, Osamu Satoh, Noriaki Kanaya, Shin Kawana, Hideaki Tsuchida, Akiyoshi Namiki |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Sapporo Medical University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 1 |
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| Page | 67-70 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」We evaluated the effect of prostaglandin E1 (PGE1) infusion on plasma concentrations of lidocaine injected into the epidural space during lower abdominal surgery. Fourteen female patients undergoing gynecologic surgery under epidural blockade plus general anesthesia were divided into two groups. In the PGE1 group (n=7), 0.02 μg・kg-1・min-1 of PGE1 was administered intravenously during surgery. In the control group (n=7), patients were not given PGE1. Plain 1.5 % lidocaine solution was injected through the epidural catheter by 10 ml bolus, followed by continuous administration of 8 ml・h-1. There was no significant difference in the plasma lidocaine concentrations over 120 min after initial injection of lidocaine between the two groups. However, the concentration at 180 min after initial injection in the PGE1 group was significantly lower than that in the control group (p<0.05). The maintained hepatic blood flow by PGE1 may contribute to this result. |
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| Practice | Basic medicine |
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| Keywords | Plostaglandin E1, Plasma lidocaine concentration, Epidural blockade. |
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