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| Title | Disparate Hemodynamic Responses to Injections of Methylprednisolone in a Septic Shock Patient with Long-term Catecholamine Administration |
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| Authors | Kohki Nishikawa*, Yoshihito Ujike*, Kazuo Yamaya*, Naoyuki Fujimura**, Akiyoshi Namiki** |
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| Authors(kana) | |
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| Organization | *Intensive Care Unit, Sapporo Medical University, **Department of Anesthesiology, Sapporo Medical University |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 1 |
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| Page | 84-87 |
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| Year/Month | 1997/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | uIntroductionvSeptic shock patients are usually given large doses of exogenous catecholamines to maintain the hemodynamic state. However, long-term catecholamine administration induces resistance to catecholamine presumably due to decreases in the À-adrenergic receptors which is calledgdown-regulation of À-receptorsh1`12). This is commonly due to disturbance of the adenylate cyclase system. On the other hand, several investigations have showed that large doses of steroid hormones are able to improve the deterio-rated hemodynamics in septic shock patients4`12). We observed a marked improvement in blood pressure by a different mechanism after administration of 2000 mg methylprednisolone in a septic shock patient under long-term treatment with catechol-amine. |
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| Practice | Basic medicine |
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