| Japanese |
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| Title | ドパミンとアムリノンが麻酔中の肺内シャント率に及ぼす影響 |
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| Subtitle | 原著 |
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| Authors | 唐澤富士夫, 高松功, 森和久, 足立裕史, 橋本賢, 内橋慶隆, 佐藤哲雄 |
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| Authors(kana) | |
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| Organization | 防衛医科大学校麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 18 |
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| Number | 2 |
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| Page | 190-195 |
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| Year/Month | 1997/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」肺内シャントに及ぼすドパミンとアムリノン併用投与の影響を呼吸器系の合併症のない麻酔症例で検討した. 低用量のドパミン(4μg・kg-1・min-1)またはアムリノン(10μg・kg-1・min-1＋1mg・kg-1静注)は心係数を増加させたが, 肺内シャント率には有意の変化を及ぼさなかった. 両薬物の併用投与により心係数は更に増加傾向を示し, 平均肺動脈圧, 肺血管抵抗係数, 体血管抵抗係数は低下し, 肺内シャント率は11.4±3.0％に有意に増加した. 従って, ドパミンとアムリノンの併用は循環系に対する増強作用と共に肺内シャントを増加する作用があると考えられ, 呼吸不全のある症例ではガス交換が低下する可能性が示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Dopamine, Amrinone, Pulmonary shunt |
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| English |
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| Title | Effects of Dopamine and Amrinone on Pulmonary Shunt in Patients Anesthetized with Isoflurane |
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| Subtitle | |
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| Authors | Fujio Karasawa, Isao Takamatsu, Kazuhisa Mori, Yushi Adachi, Ken Hashimoto, Yoshitaka Uchihashi, Tetsuo Sato |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, National Defense Medical College |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 2 |
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| Page | 190-195 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The effects of dopamine and amrinone on pulmonary shunt were evaluated in patients undergoing major abdominal surgery under isoflurane anesthesia. None of the patients had respiratory disease. Either a low dose of dopamine (4μg・kg-1・min-1), amrinone (1mg・kg-1 bolus administration followed by 10μg・kg-1・min-1), or a combination of the two was administered, and hemodynamic evaluation and arterial and mixed venous blood gas analysis were performed. Dopamine or amrinone alone induced slight hemodynamic changes ; increased cardiac index by both drugs, and increased heart rate and decreased systemic vascular resistance index by amrinone. Combined infusion of dopamine and amrinone increased cardiac index, and decreased pulmonary arterial pressure and both systemic and pulmonary arterial vascular resistance indices. However, PaO2 was not changed significantly. Dopamine did not affect pulmonary shunt. Pulmonary shunt before administration of amoinone was 7.4±2.0%, which was changed non-significantly to 10.9±2.8% after amrinone. However, the combination of dopamine and amrinone increased pulmonary shunt significantly. The authors conclude that a low dose of dopamine or amrinone alone dose not affect pulmonary shunt or gas exchange under isoflurane anesthesia, but that combination of the two drugs enhances pulmonary shunt. These findings may suggest that the combination of dopamine and amrinone might negatively affect gas exchange in patients with respiratory disease. |
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| Practice | Basic medicine |
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| Keywords | Dopamine, Amrinone, Pulmonary shunt |
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