| Japanese |
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| Title | ハロタン麻酔下虚血心に対する心臓交感神経刺激の影響 |
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| Subtitle | 原著 |
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| Authors | 加地省三*1, 神山有史*2 |
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| Organization | *1公立学校共済組合四国中央病院麻酔科, *2小松島赤十字病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 18 |
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| Number | 2 |
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| Page | 218-225 |
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| Year/Month | 1997/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」高度の冠動脈狭窄を施した雑種イヌ10頭を用いて, ハロタン吸入とハロタン吸入中の心臓交感神経刺激が心筋虚血に及ぼす影響を調べた. 冠動脈狭窄の程度は対照血流量の約50％とし, 代謝性の血管拡張を抑える為にプロプラノロールを0.5mg/kg投与した. ハロタン吸入濃度は0.5％とし, 左星状神経節前枝を電気刺激して心臓交感神経刺激を行った. 結果として, ハロタン吸入により冠灌流圧は低下し心筋虚血は悪化した. その状態に心臓交感神経刺激が加わると, 冠灌流圧が増大したにもかかわらず心筋虚血は悪化し, これは対照群(ハロタン吸入前)に対する心臓交感神経刺激の効果と異なった. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Halothane, Cardiac sympathetic nerve stimulation, Myocardial ischemia, Metabolic coronary vasodilation |
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| English |
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| Title | Effects of Halothane Inhalation and Cardiac Sympathetic Nerve Stimulation on Myocardial Ischemia in Canine Hearts with Severe Coronary Stenosis |
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| Authors | Shozo Kaji*1, Arifumi Kohyama*2 |
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| Authors(kana) | |
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| Organization | *1Department of Anesthesiology, Shikoku Central Hospital, *2Department of Anesthesiology, Komatsushima Red Cross Hospital |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 2 |
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| Page | 218-225 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The present study investigated the effects of halothane inhalation and cardiac sympathetic nerve stimulation during halothane inhalation on myocardial ischemia in dogs with severe coronary artery stenosis. Coronary artery stenosis was induced under fentanyl anesthesia by reducing myocardial blood flow to approximately 50% of control values. Thereafter, 0.5mg/kg propranolol was administerd in order to prevent metabolic coronary vasodilation during cardiac sympathetic nerve stimulation. Halothane was inhaled at an inspiratory concentration of 0.5%. The cardiac sympathetic nerve was stimulated electrically before and during halothane inhalation. Before halothane inhalation, cardiac sympathetic nerve stimulation did not worsen myocardial ischemia. However, halothane inhalation decreased coronary perfusion pressure in the stenotic region resulting in aggravation of myocardial ischemia. Cardiac sympathetic nerve stimulation during halothane inhalation further worsened myocardial ischemia despite an increase in coronary perfusion pressure and myocardial blood flow in the stenotic region. These results suggest that halothane inhalation aggravates myocardial ischemia through a decrease in coronary perfusion pressure that results from a decrease in aortic pressure. In addition, cardiac sympathetic nerve stimulation during halothane inhalation further aggravates myocardial ischemia. However, the mechanism associated with this aggravation differs from that before halothane inhalation. Following cardiac sympathetic nerve stimulation during halothane inhalation, myocardial ischemia probably becomes aggravated through a decrease or less pronounced increase in coronary blood flow in the myocardial inner layer caused by metabolic coronary vasodilation in the outer layer distal to the stenosis. |
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| Practice | Basic medicine |
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| Keywords | Halothane, Cardiac sympathetic nerve stimulation, Myocardial ischemia, Metabolic coronary vasodilation |
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