| Japanese |
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| Title | 一酸化窒素の末梢循環調節に対するセボフルランの影響-マイクロスフェアーを用いたin vivo study- |
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| Subtitle | 原著 |
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| Authors | 水本靖 |
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| Authors(kana) | |
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| Organization | 帝京大学医学部麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 18 |
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| Number | 3 |
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| Page | 352-358 |
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| Year/Month | 1997/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」セボフルランの血管拡張作用に一酸化窒素の関与が想定されている. 一方, in vitroの実験で一酸化窒素の血管拡張作用はハロゲン化麻酔薬で抑制されると報告されている. そこで, イヌで臓器血管抵抗に対するセボフルランの用量依存性と一酸化窒素の関与について, NO合成酵素(NOS)阻害薬のL-NAMEを用い, マイクロスフェアー法にて検討した. L-NAMEによる血管抵抗の増加率がセボフルランの1.25MAC群で0.75MAC群より冠血管, 肺, 膵臓, 胃, 筋肉で有意に低下し, 一酸化窒素の血管拡張に対するセボフルランの用量依存性抑制が認められ, in vitroの成績と一致する結果が得られた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Nitric oxide, Sevoflurane, L-NAME, Vascular resistance, in vivo |
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| English |
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| Title | The Effects of Sevoflurane on Nitric Oxide-dependent Vasodilation -in vivo Study Using Radioactive Microspheres- |
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| Subtitle | |
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| Authors | Kiyoshi Mizumoto |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Teikyo University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 3 |
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| Page | 352-358 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | It is assumed that nitric oxide contributes to vasodilation effect of sevoflurane. But recently, it has been suggested that halogenated anesthetics inhibit endothelium-dependent relaxation in vitro study. Therefore, we examined the interaction between sevoflurane and endothelium dependent nitric oxide using nitric oxide synthase (NOS) inhibitor, NW-nitro-L-arginine methyl ester (L-NAME), in vivo. Twenty-one mongrel dogs were distributed into three groups (0.75, 1.0 and 1.25MAC of sevoflurane). Radioactive microspheres were used to determine regional blood flow, before and 10 minutes after L-NAME (10mg/kg) injection. The rate of vascular resistance increase caused by L-NAME, 1.25MACsevoflurane inhibits significantly compared to 0.75MAC sevoflurane at coronary, lung, pancreas, stomach and muscle vessels. These data indicate that sevoflurane inhibits endothelium-dependent relaxation caused by nitric oxide in dose dependent manner, in vivo study. It is coincided with previous data in vitro study. |
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| Practice | Basic medicine |
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| Keywords | Nitric oxide, Sevoflurane, L-NAME, Vascular resistance, in vivo |
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