English
TitleComparison of Vasodilation Potency between Sufentanil and Fentanyl on the Isolated Aorta of the Rat
Subtitle
AuthorsFujio Karasawa*1, Victor Iwanov*2, Rovert FW Moulds*1, Tetsuo Satoh*2
Authors(kana)
Organization*1Department of Anesthesiology, National Defense Medical College, *2Department of Clinical Pharmacology, University of Melbourne, The Royal Melbourne Hospital
JournalCirculation Control
Volume18
Number3
Page359-363
Year/Month1997/
ArticleOriginal article
PublisherJapan Society of Circulation Control
Abstract[Abstract] Sufentanil and fentanyl have a weak vasodilative effect and their vasodilation is endothelium-independent and partially through an α-adorenoceptor blocking effect. The aim of the present study was to evaluate the vasodilation potency of sufentanil and fentanyl utilizing pA2, which represents the negative logarithm of an antagonist that causes a doubling of the concentrarion of an agonist to compensate for the action of the antagonist. We measured phenylephrine-induced isometric tension of rat aortic rings without endothelium suspended in organ chambers. Incubation with sufentanil, fentanyl, or phentolamine dose-dependently shifted the concentration-contraction relationships of phenylephrine to the right and sufentanil, fentanyl, or phentolamine (greater then 5×10-6, 1×10-7, or 5×10-8 mol・l-1, respectively) significantly increased the estimated concentration of phenylephrinetoinduceahalf-maximalcontraction (EC50). The pA2 values of sufentanil, fentanyl, and phentolamine, obtained from the relationships between the antagonist concentrations and EC50 ratios with to without antagonists, were 4.92, 6.10, and 7.04, respectively. Therefore, the inhibitory effects of sufentanil on phenylephnne-induced vasoconstriction are 1/15 as potent as fentanyl.
PracticeBasic medicine
KeywordsAnesthetics, opioid : sufentanil ; fentanyl. α-Adrenergic receptor agonists : phenylephrine. Vascular smooth muscle : vasodilation. Arteries : aorta. Animal : rat.

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