| English |
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| Title | Effects of Flumazenil on Function and Metabolism in the Ischemic Working Rat Heart |
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| Subtitle | |
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| Authors | Toshiaki Yamaguchi, Satoshi Kashimoto, Takeshi Oguchi, Teruo Kumazawa |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Yamanashi Medical University |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 3 |
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| Page | 364-368 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | [Abstract] We examined the effects of benzodiazepine antagonist, flumazenil, on myocardial function and metabolism in the ischemic working rat heart preparation. Animals were divided into three groups. The one was control group and the others were flumazenil, 10-5 and 10-6 M・L-1 groups. The hearts were perfused with Krebs-Henseleit bicarbonate (KHB) buffer. After the control perfusion, whole heart ischemia was induced by clamping a one-way aortic valve bypass for 15 min followed by reperfusion for 20 min. In the flumazenil groups, flumazenil was administered to KHB buffer during the reperfusion period. The mechanical performance in all groups was impaired after ischemia, but there were no significant defferences in the recovery of cardiac output, peak systolic pressure, coronary flow and LV dP/dT maximum among the groups. Ventricular fibrillation occurred in all hearts except for one heart in the flumazenil 10-6 M group. There were also no significant differences in high energy phosphates, glycogen and lactate concentrations among the groups. These results suggest that flumazenil has no adverse effects during post-ischemic reperfusion. |
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| Practice | Basic medicine |
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| Keywords | Flumazenil, Myocardial ischemia, Myocardial metabolism, Working rat heart perparaton |
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