| English |
|---|
| Title | Exercise Gas Exchange in Heart Failure : Central and Peripheral Factors |
|---|
| Subtitle | |
|---|
| Authors | Karlman Wasserman |
|---|
| Authors(kana) | |
|---|
| Organization | Division of Respiratory and Critical Care Medicine, Department of Medicine, Harbor-UCLA Medical Center |
|---|
| Journal | Circulation Control |
|---|
| Volume | 18 |
|---|
| Number | 4 |
|---|
| Page | 525-534 |
|---|
| Year/Month | 1997/ |
|---|
| Article | Report |
|---|
| Publisher | Japan Society of Circulation Control |
|---|
| Abstract | [Introduction] In recent years, attention has been directed at the mechanism for exercise intolerance in patients with chronic heart failure (HF). Chronic HF is associated with impaired myocardial function which limits the heart's ability to increase cardiac output in response to exercise to the level normally required (central factor)1～4). However, recent experimental work demonstrated that the skeletal muscle is abnormal in chronic HF patients (peripheral factor)5～10) and this might account for the limited ability of HF patients to exercise. The peripheral factors that have been described take two forms. One is a reduction in aerobic enzymes which impairs the rate of substrate flow through the tricarboxylic acid cycle and therefore the rate of high energy phosphate regeneration needed for exercise5, 8). |
|---|
| Practice | Basic medicine |
|---|
| Keywords | |
|---|