| English |
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| Title | Effects of Inhalation Anesthetics on Cardiac Function and Metabolism after Coronary Ligation in the Isolated Rat Heart |
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| Subtitle | |
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| Authors | Satoshi Kashimoto, Masaki Kume, Akihiko Nonaka, Teruo Kumazawa |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Yamanashi Medical University |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 4 |
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| Page | 555-560 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | [Abstract and key words] We have evaluated the cardiac effects of inhalation anesthetics on the isolated perfused rat heart after coronary ligation. An isolated rat heart-lung preparation was used. Forty-nine male Wistar rats weighing 300-320g were randomly divided into five groups. All rats except in the control group (they were anesthetized with isoflurane) were anesthetized with each inhalation anesthetic during the preparation and they received no inhalation anesthetic (control), 1% halothane, 2.2% enflurane, 1.4% isoflurane or 2.5% sevoflurane during the perfusion. The heart was perfused initially at a cardiac output of 30ml/min and a mean arterial pressure of 70mmHg. Eight min after the start of perfusion, the left anterior descending coronary artery was ligated. Thirty min after the perfusion, the heart was divided into infarcted and non-infarcted parts and freeze-dried for 6 days. Halothane and enflurane decreased systolic blood pressure significantly when compared with the control after coronary ligation. However, only enflurane reduced cardiac output after coronary ligation. In all groups, myocardial ATP levels in infarcted parts were significantly lower than those in non-infarcted parts. In addition, myocardial ADP, AMP and lactate levels in infarcted parts were significantly higher than those in non-infarcted parts. However, there were no significant differences in high energy phosphates and lactate levels among the groups. Enflurane produced lower blood pressures and lower cardiac output than those seen in the control and other anesthetic agents. Attention should be paid when a patient with ischemic heart disease is anesthetized with enflurane. However, any inhalation anesthetics examined in the present study did not influence the myocardial metabolism. |
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| Practice | Basic medicine |
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| Keywords | Cardiac metabolism, Inhalation anesthetics, Myocardial infarction. |
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