| Japanese |
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| Title | 高度脳静脈還流障害による経リンパ脳脊髄液吸収路の遮断 |
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| Subtitle | 原著 |
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| Authors | 諏訪一郎 |
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| Authors(kana) | |
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| Organization | 大阪歯科大学歯科麻酔学講座 |
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| Journal | 循環制御 |
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| Volume | 18 |
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| Number | 4 |
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| Page | 567-576 |
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| Year/Month | 1997/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」脳静脈還流障害時の頸部リンパ系への脳脊髄液(CSF)吸収の変化を知る目的で, ラット脳室内へ注入したIndia inkの後頸リンパ節(PCLN)への移行を検討した. 頭蓋内圧(ICP)正常群(N群), ICP亢進群(H群), 脳静脈還流障害群(V群)の3群につき, PCLNへ色素が排出されるまでの時間(t)を測定した. さらに, 篩状板を中心に硬膜外への色素漏出を組織学的に観察した. その結果, N群に比べH群のtは短縮し, 個々のICPとtの間に負の相関関係を認めた. しかし, V群の75%ではPCLN着色は観察されず, 組織学的にも鼻粘膜への色素浸透は認められなかった. なお, 静脈還流障害60分後の脳水分含量は増加した. すなわち, ICPが亢進するほど, 経リンパCSF吸収路の機能は大きくなり圧制御作用を発揮するが, 短時間に脳浮腫が発現するような高度脳静脈還流障害時には, 逆に, リンパへの吸収が障害される危険性が示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Cerebrospinal fluid, Intracranial pressure, Absorption, Lymph |
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| English |
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| Title | Blockage of the Lymphatic Absorptive Pathway of Cerebrospinal Fluid Owing to Severe Impairment of Cerebral Venous Return |
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| Subtitle | |
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| Authors | Ichirou Suwa |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Osaka Dental University |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 4 |
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| Page | 567-576 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | To clarify changes in drainage of cerebrospinal fluid (CSF) into the deep cervical lymph nodes owing to marked impairment of cervical venous return, The author infused India ink into the rat subarachnoid space and evaluated its transfer into the lymph nodes. The author measured the time required for drainage of the India ink into the lymph nodes, and histologically examined the state of dye permeation in three groups. The first had normal intracranial pressure (ICP), the second, intracranial hypertension due to intraventricular volume loading, and the third, impaird cerebral venous return. An increase in intracranial pressure increased the lymphatic CSF absorptive function as a compensatory mechanism. Conversely, this function was impaired during severe impairment of cerebral venous return rapidly inducing cerebral edema. |
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| Practice | Basic medicine |
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| Keywords | Cerebrospinal fluid, Intracranial pressure, Absorption, Lymph |
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