| Japanese |
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| Title | イヌの開心術におけるtriiodothyronine投与の心筋代謝に及ぼす影響〜投与方法・量の検討〜 |
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| Subtitle | 特集 第18回日本循環制御医学会総会シンポジウム(II)若手研究者シンポジウム |
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| Authors | 村井則之, 片山康, 山田崇之, 今関隆雄, 入江嘉仁, 長澤城幸, 佐野英基, 木山宏, 垣伸明, 佐藤康広, 秦一剋 |
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| Organization | 獨協医科大学越谷病院心臓血管外科 |
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| Journal | 循環制御 |
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| Volume | 19 |
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| Number | 1 |
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| Page | 13-19 |
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| Year/Month | 1998/ |
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| Article | 報告 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」triiodothyronine(T3)を投与し心筋代謝を検討した. イヌにて, 60分間の心停止を行った. T1群(n=8)は大動脈遮断直後, T3 : 0.1μg/kg/minを経静脈に投与し, T2群(n=3)は遮断直後の投与に加え7日前よりT3 : 150μg/dayを経口投与し非投与群(n=7)と検討した. T1群で頻脈はなく心拍出量は高い傾向を示した. T1群では再灌流後, 酸素, 乳酸およびブドウ糖摂取量は増大した. 脂肪酸摂取量は全群で低下した. 乳酸/ピルビン酸比よりT3作用は心筋に特異的で, 代謝効率はT1群で良好だった. T2群で微細構造障害がみられ, 過量投与は有害だった. 「緒言」人工心肺を用いての開心術後, 血中甲状腺ホルモン濃度が低下することは知られている1〜7). その低下の原因としては多数の因子1〜5)が考えられ, 証明されている. 臨床的に確かめてみると, 開心術後血中triiodothyronine(T3)は確かに減少していた(図1). |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Open heart surgery, Myocardial oxygen consumption, Lactate/pyruvate ratio, Triiodothyronine, Mongrel dogs |
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| English |
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| Title | Effect of Thyroid Hormone on the Myocardial Metabolism Following Open-heart Surgery in Mongrel Dogs |
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| Authors | Noriyuki Murai, Yasushi Katayama, Takashi Yamada, Takao Imazeki, Yoshihito Irie, Shiroyuki Nagasawa, Eiki Sano, Hiroshi Kiyama, Nobuaki Kaki, Yasuhiro Satou, Ikkoku Hata |
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| Authors(kana) | |
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| Organization | Department of Cardiovascular and Thoracic Surgery, Dokkyo University Koshigaya Hospital |
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| Journal | Circulation Control |
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| Volume | 19 |
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| Number | 1 |
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| Page | 13-19 |
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| Year/Month | 1998/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The effect of triiodothyronine (T3) on the myocardial metabolism was studied in mongrel dogs with 60 min of normothermic crystalloid cardioplegic arrest. Animals were divided into three groups : control (n=7), group T1 (n=8) which received T3 (0.1μg/kg/min) intravenously after aortic cross-clamping, and group T2 (n=3) which received oral T3 (150μg/day) preoperatively for 7 days and intravenous T3 (0.1μg/kg/min) after aortic cross-clamping. Myocardial oxygen, lactate, glucose and free fatty acid uptake, arterial lactate/pyruvate ratio and coronary sivus lactate/pyruvate ratio were measured before, immediately after and, 30, 60, and 120 min following the release of aortic cross-clamping. T1 increased myocardial oxygen, lactate and glucose uptake. Control group and T2 group showed no change in myocardial uptake of oxygen, lactate and glucose. No difference was observed in the myocardial uptake of free fatty acid in three groups. Reviewing the changes in the arterial lactate/pyruvate ratio and coronary sivus lactate/pyruvate ratio to oxygen consumption, it is clearly shown that the metabolic improvement by T3 is specific to the myocardium and more efficient in the T1 group. Microarchitecture of T2 group was injured. Our results showed that T3 administration makes myocardial metabolism more hyperactive, and increases substrate uptake. Excessive doses of T3 might be harmful for microarchitecture and myocardial metabolism. |
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| Practice | Basic medicine |
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| Keywords | Open heart surgery, Myocardial oxygen consumption, Lactate/pyruvate ratio, Triiodothyronine, Mongrel dogs |
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